April 2014
Volume 55, Issue 13
ARVO Annual Meeting Abstract  |   April 2014
Diagnostic findings identified by ultra-widefield fluorescein angiography in uveitis patients
Author Affiliations & Notes
  • Kathleen Farhang
    Case Western Reserve University School of Medicine, Cleveland, OH
  • Kimberly Baynes
    Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH
  • Francesco Pichi
    University Eye Clinic, San Giuseppe Hospital, Milan, Italy
  • Careen Y Lowder
    Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH
  • Sunil K Srivastava
    Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH
  • Footnotes
    Commercial Relationships Kathleen Farhang, None; Kimberly Baynes, None; Francesco Pichi, None; Careen Lowder, Clearside (C), Santen (C); Sunil Srivastava, Alimera (C), Allergan (F), Bausch and Lomb (C), Bausch and Lomb (F), Bioptigen (P), Clearside (C), Clearside (F), Novartis (F), Regeneron (C)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 261. doi:
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      Kathleen Farhang, Kimberly Baynes, Francesco Pichi, Careen Y Lowder, Sunil K Srivastava; Diagnostic findings identified by ultra-widefield fluorescein angiography in uveitis patients. Invest. Ophthalmol. Vis. Sci. 2014;55(13):261.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: Ultra-widefield fluorescein angiography (UWFFA) is an emerging technology that allows for improved visualization of the retinal periphery. The additional information offered by retinal periphery visualization may alter diagnosis, management, and treatment of many retinal conditions. We aimed to identify changes seen using UWFFA in patients with uveitis and ocular inflammatory diseases.

Methods: An IRB approved retrospective, observational consecutive case series of ophthalmic patients with uveitis at the Cleveland Clinic Foundation Cole Eye Institute was performed. All patients underwent comprehensive ophthalmic exam and UWFFA with the Optos 200Tx system. High magnification views were compared to the ultra-widefield FA to simulate standard 50-degree fundus images. Any findings outside the range of a standard fluorescein angiogram were documented.

Results: 116 patients with uveitis that required fluorescein angiography were included in the study. A total of 231 visits resulted in 458 sets of ultra-widefield FA images. Of the study population, 63.8% were female. The most common diagnoses included sarcoidosis, retinal vasculitis, idiopathic panuveitis, birdshot retinopathy, and intermediate uveitis. 71.2% of ultra-widefield images yielded information that would not have been found with standard imaging technology. Retinal findings outside the standard FA view included: peripheral non-perfusion (23.1%), focal vessel leakage (41.9%), diffuse leakage (70.9%), chorioretinal scars (19.7%), and multifocal lesions (7.7%).

Conclusions: Standard 50-degree fundus photography may not detect clinically important abnormalities that may be more easily and accurately documented with UWFFA. In the management of certain subtypes of uveitis including retinal vasculitis, intermediate uveitis and ocular sarcoidosis, imaging of the retinal periphery with the Optos 200Tx system has added value over standard fundus photography.

Keywords: 550 imaging/image analysis: clinical • 688 retina  

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