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yoshihiro kaizu, Shintaro Nakao, Shigeo Yoshida, Tatsuro Ishibashi; Spontaneous Remission of Acute Zonal Occult Outer Retinopathy: Follow-up Using Adaptive Optics Scanning Laser Ophthalmoscopy. Invest. Ophthalmol. Vis. Sci. 2014;55(13):2614.
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© ARVO (1962-2015); The Authors (2016-present)
The purpose of this study was to report a case of acute zonal occult outer retinopathy (AZOOR) with spontaneous remission that followed up using Adaptive Optics Scanning Laser Ophthalmoscopy (AO-SLO).
The right eye of a 31-year old myopic man diagnosed with AZOOR was followed up. The patient underwent a full ophthalmologic examination, spectral-domain optical coherence tomography (SD-OCT), multifocal electroretinography (mfERG) and imaging with prototype AO-SLO systems (Canon Inc) at the first visit, 1month after and 2 months after. Images focused on the photoreceptor layer were recorded in area, and a montage of AO-SLO images was created.
The patient presented with acute onset of a blind spot and photopsia in his right eye. On AO-SLO, focal dark areas could be observed on the right eye but not on the left eye at the first examination (cone density; 8589/mm2, mosaic regularity of cone photoreceptors; 38.5%, cone spacing; 0.567). The dark areas on AO-SLO were correspondent to areas of disrupted IS/OS line and abnormal area in mfERG. After 1 and 2 months, his symptoms tended to disappear gradually without any treatment. IS/OS line and mfERG could be nearlynormarlized. Furthermore, normal cone mosaic could be observed in areas where some focal dark spots could be observed at the first examination (cone density; 10112/mm2, mosaic regularity of cone photoreceptors; 39.9%, cone spacing; 0.606).
AO-SLO is a useful tool of diagnosis and follow-up of AZOOR. This study might suggest reversible cone damage could occur in some cases of AZOOR with spontaneous remission.
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