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Jung Yeul Kim, Sung Bok Lee, Kyung Nam Kim, Haeng Jin Lee; The effect of serous retinal detachment on analysis of ganglion cell layer through the utilization of spectral domain Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2014;55(13):2622.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the effect of serous retinal detachment on ganglion cell layer (GCL) analysis by spectral domain optical coherence tomography (OCT) in central serous chorioretinopathy (CSC).
We analyzed thickness of the ganglion cell layer in patients who visited hospital with first episode of CSC from January, 2011 to June, 2012. We obtained GCL thickness map from SD-OCT (Cirrus®, Carl Zeiss Meditec, Dublin, CA) at the time of initial visit and after the absorption of subretinal fluid. The GCL thickness at the time of initial visit and after the absorption of subretinal fluid in both affected and fellow eye was measured.
Total 30 patients with CSC were included. At the time of initial visit and after the absorption of subretinal fluid, the average GCL thickness were 66.2±17.1 µm and 81.3±8.9 µm respectively, showing a statistically significant difference (p<0.001). Compared to that of fellow eye, the average GCL thickness in affected eye at the first visit was significantly thinner (p<0.001). However, after the absorption of subretinal fluid, the average GCL thickness in affected eye and fellow eye didn’t show any significant difference. When GCL thickness was investigated by sectors provided by map, the GCL thickness in sectors not associated with retinal elevation was measured to be significantly thinner.
According to the analysis of GCL in patients with CSC, the GCL thickness may be affected by retinal contour abnormalities. Therefore, during analyzing GCL thickness in various eye disease including retinal disease or glaucoma, the change of retinal contour would be considered.
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