April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Measurement of progression of Gyrate Atrophy using Ultra-Wide Field fundus photography
Author Affiliations & Notes
  • Miguel Paciuc-Beja
    Ophthalmology, Denver Health Medical Center, Denver, CO
    Rocky Mountain Lions Eye Institute, University of Colorado School of Medicine, Aurora, CO
  • Guillermo Salcedo
    Ophthalmology, Denver Health Medical Center, Denver, CO
    Rocky Mountain Lions Eye Institute, University of Colorado School of Medicine, Aurora, CO
  • Jesse M Smith
    Rocky Mountain Lions Eye Institute, University of Colorado School of Medicine, Aurora, CO
  • Mariana Harasawa
    Ophthalmology, Denver Health Medical Center, Denver, CO
  • Raul Velez-Montoya
    Rocky Mountain Lions Eye Institute, University of Colorado School of Medicine, Aurora, CO
  • Jeffrey L Olson
    Rocky Mountain Lions Eye Institute, University of Colorado School of Medicine, Aurora, CO
  • Scott C Oliver
    Rocky Mountain Lions Eye Institute, University of Colorado School of Medicine, Aurora, CO
  • Naresh Mandava
    Ophthalmology, Denver Health Medical Center, Denver, CO
    Rocky Mountain Lions Eye Institute, University of Colorado School of Medicine, Aurora, CO
  • Hugo Quiroz-Mercado
    Ophthalmology, Denver Health Medical Center, Denver, CO
    Rocky Mountain Lions Eye Institute, University of Colorado School of Medicine, Aurora, CO
  • Footnotes
    Commercial Relationships Miguel Paciuc-Beja, None; Guillermo Salcedo, None; Jesse Smith, None; Mariana Harasawa, None; Raul Velez-Montoya, None; Jeffrey Olson, None; Scott Oliver, None; Naresh Mandava, None; Hugo Quiroz-Mercado, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 265. doi:https://doi.org/
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      Miguel Paciuc-Beja, Guillermo Salcedo, Jesse M Smith, Mariana Harasawa, Raul Velez-Montoya, Jeffrey L Olson, Scott C Oliver, Naresh Mandava, Hugo Quiroz-Mercado; Measurement of progression of Gyrate Atrophy using Ultra-Wide Field fundus photography. Invest. Ophthalmol. Vis. Sci. 2014;55(13):265. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To measure the progression of atrophic lesions in two patients with gyrate atrophy and establish a novel method of follow-up for this hereditary dystrophy.

Methods: A retrospective, longitudinal, observational and comparative study of two patients with gyrate atrophy. Ultra-wide field fundus photographs was performed in two consecutive visits one year apart. Solitary lesions were observed to be present in both visits, excluding atrophy that became confluent with other lesions over time. The atrophic zones were measured using the area measurement caliper software ten times to get an average due to high variability of measurements. The optic nerve was measured also to determine changes in size due to patient position in both photographs. New solitary lesions in the follow-up photograph were also measured.

Results: Thirty-two corresponding individual lesions were observed and measured. Mean growth of lesions (difference between size measured at follow-up with size at baseline) was 4418.24 pixels2, with a standard deviation of 225.0 pixels2. Pixel area of new individual lesions presented a mean of 1586.08 pixels2, with a standard deviation of 957.36 pixels2.

Conclusions: Ultra-wide field photographs can be an objective method to measure progression of atrophic lesions in patients with gyrate atrophy. High variability of individual measurements require performing repeated measurements to homogenize data.

Keywords: 696 retinal degenerations: hereditary • 550 imaging/image analysis: clinical • 688 retina  
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