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Jingyun Wang, Christopher Anderson Clark; Periphery Retinal Contour in Children with Myopia of Prematurity. Invest. Ophthalmol. Vis. Sci. 2014;55(13):2728.
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© ARVO (1962-2015); The Authors (2016-present)
Two thirds of children with retinopathy of prematurity have myopia. Unlike juvenile myopia that is associated with axial elongation after 7 years of age, myopia of prematurity (MOP) is characterized by a dramatic myopic shift during the first 1.3 years, with little additional myopic progression thereafter (Wang et al, 2013). Risk for juvenile myopia has been linked to prolate ocular shape and relative peripheral hyperopic defocus. The peripheral retina may play an important role on guiding eye growth and emmetropization. We have little knowledge about ocular shape in children with MOP. By analyzing OCT images, the aim of this study is to investigate ocular shape in children with MOP.
Two groups of 7-14 year old children were enrolled. The MOP group included six preterm children (gestational age =25.1±0.9 wk) with MOP (-2.00 to -9.00 D) and normal appearing posterior pole. The control group included 8 age-matched full-term emmetropic children. High-resolution OCT 9mm foveal scan images were analyzed across more than ±10 degrees of eccentricity. The retinal profile was segmented to identify the interface between the photoreceptor outer-segment/RPE. Slopes were calculated from the retinal profile as a quantitative measure of ocular shape.
There was greater variability within the MOP group than in the full-term control group. As an example, one subject within this group showed a retinal profile nearly twice as curved as any other subject within this study. Also, the MOP group exhibited irregular profiles compared to the relatively smooth profiles of full-term controls. There was no statistically significant difference in ocular shape (slope) between the two groups (MOP slope: -2.5±3.3; fullterm slope: -2.0±2.8, p=0.78) but slope was signficantly correlated with spherical equivalent refractive error (r=0.82, p=0.04).
Among both preterm children with MOP and fullterm controls, prolate ocular shape was associated with myopia. In addition to the anterior segment abnormalities that others have reported to be associated with MOP, these pilot results support that mechanism of MOP is associated with abnormal ocular shape.
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