April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Relationship between retinal volume and sensitivity during longitudinal follow-up: Early Markers Observational Study.
Author Affiliations & Notes
  • Ruth E Hogg
    Center for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom
  • Srinivas R Sadda
    Keck School of Medicine, University of Southern California, Los Angeles, CA
  • Zhihong Hu
    Keck School of Medicine, University of Southern California, Los Angeles, CA
  • Yan Luo
    Keck School of Medicine, University of Southern California, Los Angeles, CA
  • Rufino Silva
    Ophthalmology Unit, Centro Hospitalar e Universitário Coimbra, Coimbra, Portugal
  • Giovanni Staurenghi
    Department of Clinical Science "Luigi Sacco", University of Milan, Milan, Italy
  • Usha Chakravarthy
    Center for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom
  • Footnotes
    Commercial Relationships Ruth Hogg, None; Srinivas Sadda, None; Zhihong Hu, None; Yan Luo, None; Rufino Silva, Pfizer (F); Giovanni Staurenghi, Pfizer (F); Usha Chakravarthy, Pfizer (F)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 283. doi:
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      Ruth E Hogg, Srinivas R Sadda, Zhihong Hu, Yan Luo, Rufino Silva, Giovanni Staurenghi, Usha Chakravarthy; Relationship between retinal volume and sensitivity during longitudinal follow-up: Early Markers Observational Study.. Invest. Ophthalmol. Vis. Sci. 2014;55(13):283.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract 
 
Purpose
 

To investigate the relationship between microperimetry(MP) and tomographic metrics from automated segmentation of spectral-domain optical coherence tomography (SD-OCT).

 
Methods
 

Study sample: The overall study recruited 105 patients (53 males, 52 females) with unilateral advanced AMD from 3 Centres (Milan, Coimbra, Belfast) aged 52-93 years. Study Eye=Fellow eye without advanced disease. Best corrected distance acuity (BCVA) and near acuity (NVA), reading speed adjusted for print size (reading index; RI), low-luminance acuity were measured. Participants were assessed every six months, with a maximum follow-up of two years. High density macular raster scans on the Heidelberg HRA-OCT were obtained. Initially 35 study eyes from the Belfast centre were evaluated to assess structure function relationships. Of these 31 eyes had SD-OCT scans of sufficient quality for automated segmentation of the retina, ellipsoid zone, retinal pigment epithelium/drusen complex and choroid. OCT volumetrics were obtained in the ETDRS grid region using 3D-OCTOR software. Presence or absence of reticular drusen was assessed by trained graders. Registration between the microperimetry image and the OCTOR software enabled layer thickness at each MP loci to be calculated. Univariate analyses were employed to examine relationships between function and volumetrics, and the change in layer thickness and volume during follow-up.

 
Results
 

There was no significant change in volume of any of the layers between 6 monthly visits however retinal volume was significantly reduced between visit 1 to visit 5 (p=0.04). There was no significant difference in layer thickness or volume between those with reticular drusen and those without at baseline. There were significant decreases in retinal sensitivity and corresponding layer thicknesses over time. Significant correlations between localized retinal sensitivity and localised layer thickness were noted for the retina(r=0.28, p<0.001), ellipsoid zone (r=0.24, p<0.001), choroid (r=0.24, p<0.001) but not for the RPE/drusen layer (r=0.27, p<0.001).

 
Conclusions
 

Longitudinal analyses of the OCT automated segmentation shows that change in thickness of individual retinal layers is detectable throughout follow-up. Microperimetry deficits appear to correspond to OCT morphological features.

 
Keywords: 550 imaging/image analysis: clinical • 758 visual fields • 412 age-related macular degeneration  
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