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Yoon Hyung Kwon, Nam Yeong Kim, Yeon A Kim, Won Yeol Ryu, Hee-Bae Ahn; Association of toxocara infection with central serous chorioretinopathy (CSC). Invest. Ophthalmol. Vis. Sci. 2014;55(13):2843.
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The aim of this study is to evaluate the seroprevalence of toxocara infection in patients with central serous chorioretinopathy(CSC)
Retrospective observational case series. A group of 28 patients with diagnosis of CSC, confirmed by fluorescein angiogram and optical coherence tomography, and a control group of 75 patients referred to our department for retinal disease other than CSC were studied. Each patients provided serologic test (ELISA) of toxocara spp, we compared the seroprevalence of two groups.
28 patients had CSC (M:F = 24:4, mean age 52.4±7.68 years) and 75 patients (M:F = 32:43, mean age 48.5±14.2 years) were in control group. The seroprevalence of toxocara infection was 78.57% in CSC group, and 25.3% in control group (P ≤ 0.001, by Fisher exact test). For correction of difference between the two groups in the sex ratio (large male), we've targeted male patients. CSC group (24 male patients, mean age 52.46 ± 8.23 years) was 79.16%, the control group (32 male patients, mean age 46.06 ± 13.97 years) was 31.25%. The seroprevalence of two groups (male patients) shows a statistically significant difference (P ≤ 0.001, by Fisher exact test).
The results of this study show that the seroprevalence of toxocara infection seems to be significantly higher in patients with CSC than in controls. This difference may represent that toxocara infection may be possibly associated with CSC.
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