April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Endophthalmitis Caused by Streptococcal Species: Clinical Settings, Microbiology, Management, and Outcomes.
Author Affiliations & Notes
  • Harry W Flynn
    University of Miami, Miami, FL
  • Ajay Eapen Kuriyan
    University of Miami, Miami, FL
  • William Smiddy
    University of Miami, Miami, FL
  • Audina M Berrocal
    University of Miami, Miami, FL
  • Thomas Arno Albini
    University of Miami, Miami, FL
  • Darlene Miller
    University of Miami, Miami, FL
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 2857. doi:
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      Harry W Flynn, Ajay Eapen Kuriyan, William Smiddy, Audina M Berrocal, Thomas Arno Albini, Darlene Miller; Endophthalmitis Caused by Streptococcal Species: Clinical Settings, Microbiology, Management, and Outcomes.. Invest. Ophthalmol. Vis. Sci. 2014;55(13):2857.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To report the clinical settings, antibiotic susceptibilities, and outcomes of endophthalmitis caused by Streptococcus species

Methods: Retrospective, single-center, observational case series, evaluating all patients with culture-positive endophthalmitis caused by Streptococcus species between January 1, 2000 and December 31, 2011.

Results: Study criteria were met by 63 patients. The most common clinical settings were bleb-associated (17, 27%), post-intravitreal injection (16, 25%), and post-cataract surgery (13, 21%). The isolates were S. viridans (47, 71%), S. pneumoniae (13, 21%), and β-hemolytic Streptococci (5, 8%). Sixty (95%) of 63 isolates were susceptible to vancomycin, 47 (98%) of 48 to ceftriaxone (third generation cephalosporin), and 57 (93%) of 61 to levofloxacin (third generation fluoroquinolone). Between the first and second half of the study period, the minimal inhibitory concentration (MIC) of antibiotics required to inhibit 90% of isolates increased by 1.5-fold for ceftriaxone and 2-fold for levofloxacin, and remained the same for vancomycin. Initial treatment was vitreous tap (49, 78%) or pars plana vitrectomy (14, 22%); all received intravitreal antibiotics. Visual acuity outcomes were variable; best corrected visual acuity (BCVA) was ≥20/400 in 16 (25%) patients and <20/400 in 47 (75%) patients. Evisceration/enucleation was performed in 16 (25%) patients.

Conclusions: Streptococcus isolates generally had high susceptibility rates to commonly used antibiotics. Higher antibiotic MICs were required to inhibit 90% of isolates in vitro in the second half of the study period compared to the first half. Despite prompt treatment, the majority of patients had poor outcomes.

Keywords: 513 endophthalmitis  
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