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Sun Ho Park, Yong Joon Kim, Kyung-Seek Choi; Pressure Difference between the Anterior Chamber and the Vitreous Cavity in Eyes with Pupillary Block. Invest. Ophthalmol. Vis. Sci. 2014;55(13):2913.
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The primary aim of this study was to measure the pressure difference between the anterior chamber and the vitreous cavity, which had been predicted with studies with mathematical models, in real eyes.
This study was conducted using vitrectomized porcine eyes. Infusion pressures of 10 to 80 mmHg were generated with vented gas forced infusion system. Measurement of pressure were obtained with digital manometry connected with 25-gauge catheters from the anterior chamber and vitreous cavity, simultaneously. After increasing the pressure of the anterior chamber to each target pressure, pressure change in the vitreous cavity were recorded, and vice versa.
The obtained intravitreal pressure was similar to the increased intracameral pressure in all cases. The obtained intracameral pressure was similar to the increased intravitreal pressure, under 50 mmHg. When increasing the intravitreal pressure to 60, 70 and 80mmHg, the obtained intracameral pressure were 57.6 ± 1.0, 64.0 ± 0.8, and 69.6 ± 2.4 mmHg, respectively. The obtained intravitreal pressures were 1.5, 5.9 and 9.1 mmHg higher than that of the obtained intracameral pressure with target pressures of 60, 70, and 80mmHg, respectively (P = 0.027, 0.001, 0.001). Pupillary block was observed in case of increasing the intravitreal pressure over 50 mmHg.
The intracameral pressure could be significantly lower than intravitreal pressure in some eyes with pupillary block. When we use the non-invasive tonometer, the possibility of underestimation of operative pressure at the optic nerve head should be considered in eyes with pupillary block.
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