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SUJIN KIM, Myeongin Yeom, SeungUk Lee, ChangZoo Kim, SangJoon Lee, JiEun Lee; Changes of peripapillary retina and retinal nerve fiber layer thicknesss in diabetic macular edema patients who response to single intravitreal anti-VEGF injection. Invest. Ophthalmol. Vis. Sci. 2014;55(13):2921.
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To evaluate the changes of thicknesses at peripapillary retina and retinal nerve fiber layer analyzed by spectral-domain optical coherence tomography in patient with diabetic macular edema and decreased macular thickness after single intravitreal bevaciaumab injection.
This is retrospective study of 21 persons (29 eyes) who have taken an intravitreal bevacizumab injection due to diabetic macular edema and responded to the single injection from November 1, 2012 to July 30, 2013 are involved. The injection day, after 3, 7 days, 1month, we check the thicknesses of macular, peripapillary retina, peripapillary retinal nerve fiber layer with SPECTRALIS OCT (Heidelberg Engineering, Germany). The measurement of macular thickness is done at central 1mm diameter, the average peripapillary retinal thickness and the maximal peripapillary RNFL thickness is checked with dividing in 6 sectors(from 12:00 o’clock to clockwise rotation 45, 90, 45, 45, 90, 45 degree) and the data are used.
The central macular thicknesses at all post-injection period have statistical significance compared to baseline (p<0.01). The maximal thicknesses of periparpillary retina have statistically significant decreases in superotemporal segment at 7 day and 1 month after intravitreal injection and in inferonasal segments at 1month (p<0.05). The thicknesses of peripapillary RNFL in all the segments have no statistical significance all the post-injective observatory period (p>0.05).
In this study, after intravitreal injection, statistically significant differences of the thicknesses at superotemporal and inferonasal segments of peripapillary RNFL are shown with the decrease of macular edema. However there are no statistically significant changes are observed at peripapillary retinal thicknesses.
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