April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Internal and External Retinal Arteriolar Diameter and Retinal Nerve Fiber Layer Thickness in Patients with Primary Open-Angle Glaucoma
Author Affiliations & Notes
  • Nausica Ghilardi
    Eye Clinic, University of Brescia, Brescia, Italy
  • Andrea Russo
    Eye Clinic, University of Brescia, Brescia, Italy
  • Damiano Rizzoni
    Medical Clinic, University of Brescia, Brescia, Italy
  • Ciro Costagliola
    Department of Health Sciences, University of Molise, Campobasso, Italy
  • Francesco Semeraro
    Eye Clinic, University of Brescia, Brescia, Italy
  • Footnotes
    Commercial Relationships Nausica Ghilardi, None; Andrea Russo, None; Damiano Rizzoni, None; Ciro Costagliola, None; Francesco Semeraro, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 2937. doi:https://doi.org/
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      Nausica Ghilardi, Andrea Russo, Damiano Rizzoni, Ciro Costagliola, Francesco Semeraro; Internal and External Retinal Arteriolar Diameter and Retinal Nerve Fiber Layer Thickness in Patients with Primary Open-Angle Glaucoma. Invest. Ophthalmol. Vis. Sci. 2014;55(13):2937. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To investigate internal and external retinal arteriolar diameters and to evaluate the relationship between retinal nerve fiber layer (RNFL) thickness and retinal arteriolar diameter in patients with primary open-angle glaucoma (POAG).

 
Methods
 

This single-site, prospective, cross-sectional study included 20 patients with POAG (20 eyes) and 20 age- and sex-matched healthy controls (20 eyes) with no history of systemic vascular disease. The internal and external diameters of the arterioles were assessed in-vivo by scanning laser Doppler flowmetry. RNFL thickness was measured using spectral-domain optical coherence tomography.

 
Results
 

Both the internal and external arteriolar diameters were smaller in eyes with POAG than in control eyes, although only the internal diameters were significantly smaller (P = 0.04 versus P = 0.23). A multivariate linear regression analysis demonstrated a significant positive correlation between RNFL thickness and both external (P = 0.024) and internal (P = 0.003) arteriolar diameters in eyes with POAG. No significant correlation was found between RNFL thickness and these variables in the control group.

 
Conclusions
 

The internal arteriolar diameter was smaller in patients with POAG than in normal subjects, and was significantly correlated with RNFL thickness in POAG patients. To our knowledge, this is the first study to report that a narrower internal arteriolar diameter may be related to RNFL thinning in POAG patients.

 
 
A scatterplot showing the relationship between retinal nerve fiber layer thickness and internal arteriolar diameter in primary open-angle glaucoma patients.
 
A scatterplot showing the relationship between retinal nerve fiber layer thickness and internal arteriolar diameter in primary open-angle glaucoma patients.
 
 
Reflection (A) and perfusion (B) images of a representative control patient compared to those of a representative primary open-angle glaucoma patient (C: reflection image; D: perfusion image).
 
Reflection (A) and perfusion (B) images of a representative control patient compared to those of a representative primary open-angle glaucoma patient (C: reflection image; D: perfusion image).
 
Keywords: 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • 610 nerve fiber layer  
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