April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Retinal capillary dropout increases over time in open-angle glaucoma patients with diabetes
Author Affiliations & Notes
  • Patrick Egan
    Ophthalmology, Indiana University School of Medicine, Indianapolis, MI
  • Alon Harris
    Ophthalmology, Indiana University School of Medicine, Indianapolis, MI
  • Brent A Siesky
    Ophthalmology, Indiana University School of Medicine, Indianapolis, MI
  • George Eckert
    Biostatistics, Indiana University School of Medicine, Indianapolis, IN
  • Yara Catoira-Boyle
    Ophthalmology, Indiana University School of Medicine, Indianapolis, MI
  • John Abrams
    Ophthalmology, Indiana University School of Medicine, Indianapolis, MI
  • Ingrida Januleviciene
    Ophthalmology, Lithuanian University of Health Sciences, Kaunas, Lithuania
  • Tara Schaab
    Ophthalmology, Indiana University School of Medicine, Indianapolis, MI
  • Annahita Amireskandari
    Ophthalmology, Indiana University School of Medicine, Indianapolis, MI
  • Footnotes
    Commercial Relationships Patrick Egan, None; Alon Harris, Adom (I), Alcon (R), Biolight (C), Merck (C), MSD (R), Nano Retina (C), ONO Pharmaceuticals (C), Pharmalight (C), Sucampo (C); Brent Siesky, None; George Eckert, None; Yara Catoira-Boyle, Alcon (C); John Abrams, None; Ingrida Januleviciene, Alcon (R), Allergan (R), Santen (R); Tara Schaab, None; Annahita Amireskandari, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 2940. doi:https://doi.org/
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      Patrick Egan, Alon Harris, Brent A Siesky, George Eckert, Yara Catoira-Boyle, John Abrams, Ingrida Januleviciene, Tara Schaab, Annahita Amireskandari; Retinal capillary dropout increases over time in open-angle glaucoma patients with diabetes. Invest. Ophthalmol. Vis. Sci. 2014;55(13):2940. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: 112 patients with OAG (21 with DM, 91 without DM) were assessed for retinal capillary blood flow as measured by Heidelberg retinal flowmetry (HRF) at baseline. 80 patients (16 with DM, 64 without DM) were assessed at 4-year follow-up. IOP was measured at both visits using Goldmann applanation tonometry. Mixed-model ANCOVA was used to test for significance of changes from baseline to 4-year follow-up with p<0.05 considered statistically significant.

Methods: In patients with DM, the number of superior zero blood flow pixels significantly increased from 0.189 (CI 95%; 0.166, 0.2140) at baseline to 0.259 (0.218, 0.309) at 4 years with a change of 0.051 (0.024, 0.074; p=0.0008). In patients without DM, the change in the number of superior zero blood flow pixels was not statistically significant (p=0.13), leading to a statistically significant difference between the two groups (p=0.0164). In patients with DM, the number of inferior zero blood flow pixels significantly increased from 0.182 (0.159, 0.209) at baseline to 0.223 (0.189, 0.264) at 4 years with a change of 0.034 (0.002, 0.060; p=0.0401). Similarly, in patients without DM, mean inferior zero pixel flow significantly increased from 0.182 (0.169, 0.196) at baseline to 0.202 (0.184, 0.222) at 4 years with a change of 0.018 (0.002, 0.033; p=0.0306). There was no significant change in IOP (p>0.05).

Results: In this cohort of patients with OAG, the amount of area with no retinal capillary blood flow increased in patients with DM over a 4-year period, but not in patients without DM. This data suggests that OAG patients with DM may have more retinal capillary dropout associated with their disease compared to OAG patients without DM.

Conclusions: In this cohort of patients with OAG, the amount of area with no retinal capillary blood flow increased in patients with DM over a 4-year period, but not in patients without DM. This data suggests that OAG patients with DM may have more retinal capillary dropout associated with their disease compared to OAG patients without DM.

Keywords: 436 blood supply • 572 ischemia • 498 diabetes  
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