April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Changes in retinal capillary blood flow correlate with changes in optic nerve head morphology in glaucoma patients with diabetes
Author Affiliations & Notes
  • John Ling
    Indiana University School of Medicine, Indianapolis, IN
  • Alon Harris
    Indiana University School of Medicine, Indianapolis, IN
  • Brent A Siesky
    Indiana University School of Medicine, Indianapolis, IN
  • George Eckert
    Biostatistics, Indiana University School of Medicine, Indianapolis, IN
  • Barbara Wirostko
    Ophthalmology, University of Utah, Salt Lake City, UT
  • Priyanka Kanakamedala
    Indiana University School of Medicine, Indianapolis, IN
  • Tara Schaab
    Indiana University School of Medicine, Indianapolis, IN
  • Annahita Amireskandari
    Indiana University School of Medicine, Indianapolis, IN
  • Footnotes
    Commercial Relationships John Ling, None; Alon Harris, Adom (I), Alcon (R), Biolight (C), Merck (C), MSD (R), Nano Retina (C), ONO Pharmaceuticals (C), Pharmalight (C), Sucampo (C); Brent Siesky, None; George Eckert, None; Barbara Wirostko, Alcon (C), Pfizer (I); Priyanka Kanakamedala, None; Tara Schaab, None; Annahita Amireskandari, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 2941. doi:
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      John Ling, Alon Harris, Brent A Siesky, George Eckert, Barbara Wirostko, Priyanka Kanakamedala, Tara Schaab, Annahita Amireskandari; Changes in retinal capillary blood flow correlate with changes in optic nerve head morphology in glaucoma patients with diabetes. Invest. Ophthalmol. Vis. Sci. 2014;55(13):2941.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To examine the relationship between changes in retinal capillary blood flow and changes in optic nerve head structure (ONH) in open angle glaucoma (OAG) patients with and without diabetes (DM).

Methods: 77 patients with OAG (15 with DM, 62 without DM) were assessed for changes in retinal capillary blood flow as measured by Heidelberg retinal flowmetry and optic nerve head morphology as measured by Heidelberg retinal topography after 4 years. Pearson correlations were used to test for associations between measurements, with p<0.05 considered statistically significant.

Results: In OAG patients with DM, change in inferior 75th percentile blood flow correlated strongly with changes in rim volume and cup to disc (C/D) area ratio (p<0.03) but not in patients without DM, resulting in a significant difference between groups (p<0.05). Inferior 90th percentile flow was significantly correlated to changes in cup area, rim area, rim volume, C/D area ratio, linear C/D ratio and cup shape (p<0.001). These relationships were not significant in patients without DM leading to a significant difference between the two groups (p<0.02). Additionally, change in inferior mean flow was strongly correlated with change in rim area, rim volume, C/D area ratio and linear C/D ratio (p<0.02) in patients with DM but not in those without DM, resulting in a significant difference between groups (p<0.03).

Conclusions: In OAG patients with diabetes, change in inferior retinal blood flow was significantly correlated with changes in ONH after 4 years. OAG patients of ED had weaker correlations, suggesting OAG patients with and without diabetes may have differences in the vascular contribution to glaucomatous structural damage. Additionally, this data suggests that there may also be regional differences in the retinal capillary beds.

Keywords: 436 blood supply • 498 diabetes • 629 optic nerve  
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