April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Non-invasive Cerebrospinal Fluid Pressure, Ocular Hemodynamic Parameters and Their Correlation with Neuroretinal Rim Area in Normal-tension Glaucoma and Healthy Controls
Author Affiliations & Notes
  • Lina Siaudvytyte
    Eye Clinic, Lithuanian University of Health Sciences, Kaunas, Lithuania
  • Ingrida Januleviciene
    Eye Clinic, Lithuanian University of Health Sciences, Kaunas, Lithuania
  • Arminas Ragauskas
    Telematics Science Laboratory of Kaunas University of Technology, Kaunas, Lithuania
  • Laimonas Bartusis
    Eye Clinic, Lithuanian University of Health Sciences, Kaunas, Lithuania
    Telematics Science Laboratory of Kaunas University of Technology, Kaunas, Lithuania
  • Alon Harris
    Eye Clinic, Lithuanian University of Health Sciences, Kaunas, Lithuania
    Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN
  • Footnotes
    Commercial Relationships Lina Siaudvytyte, None; Ingrida Januleviciene, None; Arminas Ragauskas, None; Laimonas Bartusis, None; Alon Harris, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 2949. doi:
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      Lina Siaudvytyte, Ingrida Januleviciene, Arminas Ragauskas, Laimonas Bartusis, Alon Harris; Non-invasive Cerebrospinal Fluid Pressure, Ocular Hemodynamic Parameters and Their Correlation with Neuroretinal Rim Area in Normal-tension Glaucoma and Healthy Controls. Invest. Ophthalmol. Vis. Sci. 2014;55(13):2949.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To assess differences in non-invasive cerebrospinal fluid (CSF) pressure, ocular hemodynamic parameters and to evaluate their correlation with neuroretinal rim area (NRA) in normal-tension glaucoma (NTG) and healthy controls.

Methods: 18 patients with NTG (age 56.2(10.2)) and 9 healthy controls (age 51.3(6.3)) were included in the prospective clinical trial. Non-invasive CSF pressure was measured using novel two-depth Orbital Doppler device (Vittamed 205, Kaunas, Lithuania), technology based on simultaneous blood flow signals in intracranial and extracranial segments of the ophthalmic artery (OA). Retrobulbar blood flow was measured using Color Doppler imaging (CDI, Accuvix, Seoul, Korea) in the OA and central retinal (CRA) arteries, assessing peak-systolic (PSV) and end-diastolic (EDV) velocities, and calculated resistance index (RI). Confocal laser scanning tomography (HRT, Heidelberg, Germany) was used to measure NRA. The level of significance p<0.05 was considered significant.

Results: CSF pressure was statistically significantly lower in NTG (8.08(2.64) mmHg), compared with healthy controls (10.8(2.60) mmHg), p=0.02. Patients with NTG also had decreased CRA EDV (3.57(0.86) cm/s) and increased CRA RI (0.64(0.07)), compared with healthy subjects (respectively, 4.79(1.18) cm/s and 0.58(0.06)), p<0.05. Lower CSF pressure was associated with decreased NRA (c=0.67, p=0.002) in NTG group. Lower ocular perfusion pressure was related to decreased CRA EDV (c=0.52, p=0.02) in NTG. Higher CRA RI was correlated with decreased NRA (c=-0.63, p=0.005) in healthy controls.

Conclusions: Normal-tension glaucoma patients had lower CSF pressure which correlated with decreased neuroretinal rim area. Additionally, lower ocular perfusion pressure was related with decreased CRA EDV. CSF pressure seems to be of major importance in normal-tension glaucoma and future investigations are needed to elucidate the involvement of CSF pressure in glaucoma management.

Keywords: 568 intraocular pressure • 627 optic disc  
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