April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Baseline characteristics of over 10,000 patients enrolled into the LUMINOUS study
Author Affiliations & Notes
  • Christopher S Brand
    Ophthalmology, Royal Hallamshire Hospital, Sheffield, United Kingdom
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 3061. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Christopher S Brand, LUMINOUS Study Group; Baseline characteristics of over 10,000 patients enrolled into the LUMINOUS study. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3061.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract
 
Purpose
 

To describe baseline characteristics of over 10,000 patients recruited in the LUMINOUS study

 
Methods
 

LUMINOUS is a 5-year multicenter, prospective study to evaluate long-term safety, effectiveness, treatment patterns, and health-related quality of life in patients treated in routine clinical practice with 0.5 mg ranibizumab (RBZ) in wet age-related macular degeneration [wAMD], diabetic macular edema [DME], retinal vein occlusion [RVO], and myopic choroidal neovascularization [mCNV] (depending on local approval). Consenting adult patients are enrolled irrespective of whether or not they were previously treated with RBZ and/or any other ocular therapy. Patients are excluded if they are participating in any other study that includes administration of any investigational drug, or have had systemic or ocular treatment with any vascular endothelial growth factor inhibitor other than RBZ, 90 days prior to study enrolment. The study is planned to recruit 30,000 patients from approximately 600 sites in 41 countries worldwide

 
Results
 

As of December 2013, baseline data were available for 10,071 patients. Demographic data are shown in table 1 and comorbidities in table 2. In total, 7914 (78.6%) patients were previously treated with RBZ (T1), 1891 (18.8%) patients did not have any prior treatment (T2), and 266 (2.6%) were previously treated with other ocular therapies (T3; the pre-treatment status refers to the primary treated eye). Here we present the data of T1 and T2 groups. The baseline mean visual acuity (VA) letter score of the study eye was higher in the T1 group than the T2 group across all indications (wAMD: 55.6 vs 46.4; DME: 55.3 vs 40.8; BRVO: 52.9 vs 37.3; CRVO: 45.2 vs 38.9). Mean central retinal thickness (CRT; µm) of the study eye at baseline was lower in T1 than T2 across all indications (wAMD: 265.6 vs 347.3; DME: 371.5 vs 429.3; BRVO: 328.8 vs 456.5; CRVO: 365.9 vs 555.4)

 
Conclusions
 

LUMINOUS includes patients with more diverse demographics than reported for the pivotal trials and is more representative of real world wAMD, DME and RVO patients. Previous treatment with RBZ was associated with higher VA and lower CRT at baseline than in the group without prior treatment across indications

 
 
Baseline demographic data
 
Baseline demographic data
 
 
Baseline comorbidities
 
Baseline comorbidities
 
Keywords: 412 age-related macular degeneration • 505 edema • 754 visual acuity  
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×