April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Review of anatomopathological features and high-risk factors in 45 primary enucleated eyes with retinoblastoma .
Author Affiliations & Notes
  • Alexandre Azevedo
    UNIFESP, Sao Paulo, Brazil
  • Luiz Teixeira
    UNIFESP, Sao Paulo, Brazil
  • Juliana Soares
    UNIFESP, Sao Paulo, Brazil
  • Carla D Macedo
    UNIFESP, Sao Paulo, Brazil
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 3078. doi:
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      Alexandre Azevedo, Luiz Teixeira, Juliana Soares, Carla D Macedo; Review of anatomopathological features and high-risk factors in 45 primary enucleated eyes with retinoblastoma .. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3078.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To evaluate the prevalence of high-risk factors in primary enucleated eyes with retinoblastoma diagnostic at UNIFESP/GRAAC from 2007 to 2013

Methods: Observational , retrospective study of consecutive pacients submbitted to primary enucleation at UNIFESP/GRAAC with anatomopathological diagnostic of Retiblastoma from 2007 to 2013 . The histopathological features of the enucleated specimen were reviewed after obtaining approval from the institutional review board . High-risk histopathologic features for metastatic disease were defined as the presence of 1 or more of the following : an área of massive posterior uveal invasion >or = 3 mm , post-laminar optic nerve invasion , or a combination of any nonmassive choroidal invasion with any degree of nonretrolaminar optic nerve invasion .The association between the presence of high-risk histopathological features and intraocular grouping (ICRB-international classification of retinoblastoma) , laterality , and tumor differentiation was analyzed with fisher's exact test .

Results: Of 45 eyes , 5 (11.1%) were classified as group D and 40 as E (ICRB). High-risk retinoblastoma were identified in 26 eyes (57.7%), all in Group E. Sample ages ranged from 0,5 to 85 months , median 24 months . There were choroid massive invasion in 19 eyes (42.2%) , post-laminar invasion in 11(24.4%) , and the combination of any nonmassive choroidal invasion with any degree of nonretrolaminar optic nerve invasion in 2 (4.4%). The only statistically significant association was between presence of high-risk factor and IRCB grouping (P=0.0095). Neither tumor differentiation or lateralitty showed statistically significant association with high-risk factors .

Conclusions: About half of the primary enucleated patients in our service needed adjuvant systemic chemotherapy to prevent metastatic disease. The ICRB had strong association predicting high-risk histopathologic features of retinoblastoma. Neither tumor differentiation or lateralitty showed statistically significant association with high-risk factors .

Keywords: 703 retinoblastoma • 464 clinical (human) or epidemiologic studies: risk factor assessment • 744 tumors  
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