April 2014
Volume 55, Issue 13
ARVO Annual Meeting Abstract  |   April 2014
Results of Single spot limited PDT in patients with choroidal haemangioma
Author Affiliations & Notes
  • Marilette Stehouwer
    Ophthalmology, AMC, Amsterdam, Netherlands
  • Jan E Keunen
    Ophthalmology, Radboudumc, Nijmegen, Netherlands
  • Reinier O Schlingemann
    Ophthalmology, AMC, Amsterdam, Netherlands
  • Frank D Verbraak
    Ophthalmology, AMC, Amsterdam, Netherlands
  • Footnotes
    Commercial Relationships Marilette Stehouwer, None; Jan Keunen, None; Reinier Schlingemann, None; Frank Verbraak, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 3096. doi:https://doi.org/
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      Marilette Stehouwer, Jan E Keunen, Reinier O Schlingemann, Frank D Verbraak; Results of Single spot limited PDT in patients with choroidal haemangioma. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3096. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: To study the long term outcome of patients with a circumscribed choroidal hemangioma (CCH) treated with a single spot limited photodynamic therapy (PDT) with Visudyne.

Methods: Twenty patients with a CCH were treated between 2001 and 2010 with a single spot limited PDT for CCH. The single spot covered only the most prominent part of the tumour, using a standard diode laser (692 nm), with a radiance exposure of 50 J/cm2, starting 6 min after a 1-min infusion with Visudyne (6 mg/m2 BSA). In a retrospective design the long term outcome was evaluated. Outcome parameters were: change in visual acuity (VA) pre,- and post PDT, presence of regression of the tumour on ultrasound (USG), presence and change of leakage on OCT.

Results: Regression of the tumour was seen in all patients with USG during follow up (mean follow-up 17.7 months, range 3 to 36 months). In 12 patients, the tumour became undetectable on ultrasound examination. The VA pre-PDT varied from 20/400 to 20/20, and was less than 20/40 in 10 patients. After treatment in only 5 patients VA remained below 20/40. Overall, Improvement of VA to 20/25 or higher was seen in 14 patients. In all patients, retinal leakage on OCT disappeared following PDT. Three patients had a recurrence of the CCH with retinal leakage, 4.5 , 3 and 9.3 years after PDT treatment. In all of them the tumour was still detectable after the first PDT. After retreatment with limited PDT, 2 patients recovered with a VA of 20/20, the other patient showed regression of the tumour but without improvement of VA (20/800). In the 17 patients without recurrence of leakage all parameters remained stable during follow-up.

Conclusions: Circumscribed choroidal hemangioma is effectively treated with a single spot limited photodynamic therapy with improvement of VA in the majority of cases. A recurrence can be seen especially when the tumour is not completely regressed after initial PDT.

Keywords: 744 tumors • 452 choroid • 647 photodynamic therapy  

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