April 2014
Volume 55, Issue 13
ARVO Annual Meeting Abstract  |   April 2014
Evaluation of Femtosecond Laser-assisted Clear Corneal and Paracentesis Incisions for Cataract Surgery
Author Affiliations & Notes
  • James E Hill
    Abbott Medical Optics, Santa Ana, CA
  • Brad Gray
    Abbott Medical Optics, Santa Ana, CA
  • Ling Huang
    Abbott Medical Optics, Santa Ana, CA
  • William F Wiley
    Cleveland Eye Clinic, Cleveland, OH
  • Kevin L Waltz
    Eye Surgeons of Indiana, Indianapolis, IN
  • Carrie Garufis
    Abbott Medical Optics, Santa Ana, CA
  • LeAnne Connolly
    Abbott Medical Optics, Santa Ana, CA
  • Footnotes
    Commercial Relationships James Hill, Abbott Medical Optics (E); Brad Gray, Abbott Medical Optics (E); Ling Huang, Abbott Medical Optics (E); William Wiley, Cleveland Eye Clinic (C); Kevin Waltz, Eye Surgeons of Indiana (C); Carrie Garufis, Abbott Medical Optics (E); LeAnne Connolly, Abbott Medical Optics (E)
  • Footnotes
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Investigative Ophthalmology & Visual Science April 2014, Vol.55, 3129. doi:
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      James E Hill, Brad Gray, Ling Huang, William F Wiley, Kevin L Waltz, Carrie Garufis, LeAnne Connolly; Evaluation of Femtosecond Laser-assisted Clear Corneal and Paracentesis Incisions for Cataract Surgery. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3129.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: To evaluate femtosecond laser-assisted clear corneal and paracentesis incisions on human cadaver eye tissue and in a clinical setting. Clinical trial Cleveland, Ohio, NCT01713660, 10-23-12 registered, trial start 11-6-12.

Methods: Using human eye bank tissue, one and three-plane corneal incisions, paracentesis (P) and clear corneal incision (CCI), respectively, were created using the Advanced Femtosecond Laser (iFS) laser (pulse energy 2.1 µJ, spot and layer separation of 2x2µm). CCI widths ranged from 2.2 to 3.5 mm, and P widths ranged from 0.8 to 1.2mm. Wound architecture evaluated by Optical Coherence Tomography (OCT). Corneal leakage assessed by Seidel test (with fluorescein). The iFS laser-assisted incisions were measured using Deacon-Steinert gauges. The confirmatory clinical study was performed with 10 patients (n = 10 eyes). The incision size (slit lamp beam width), architecture (OCT) and leakage (Seidel test) were evaluated immediately post laser treatment prior to cataract surgery.

Results: The iFS laser created CCI and P incisions consistently, achieving incision widths within 0.1 mm of intended target (based upon Deacon-Steinert gauge for human cadaver eye tissue and by slit lamp beam width in clinical trial). OCT scans showed that the target incision steps and depths were achieved. In all cases Seidel testing was negative, indicating the iFS laser-assisted incisions did not leak before opening them with a surgical instrument.

Conclusions: Results from these two studies (cadaver eye evaluation and clinical study) were consistent in outcomes. Clear corneal and paracentesis incisions created with the iFS laser were accurate, repeatable, and Siedel negative. OCT scans demonstrate that these incisions have a precise construction, with clear defined planes at consistent corneal depths.

Keywords: 479 cornea: clinical science • 578 laser  

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