April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Preoperative intravitreal bevacizumab on trabeculectomy with mitomycin C for neovascular glaucoma: prognostic factor for surgical failure
Author Affiliations & Notes
  • Kazuyuki Hirooka
    Ophthalmology, Kagawa Univ Faculty of Medicine, Kita-gun, Japan
  • Tetsuya Baba
    Ophthalmology, Kagawa Univ Faculty of Medicine, Kita-gun, Japan
  • Eri Nitta
    Ophthalmology, Kagawa Univ Faculty of Medicine, Kita-gun, Japan
  • Kaori Tenkumo
    Ophthalmology, Kagawa Univ Faculty of Medicine, Kita-gun, Japan
  • Shino Sato
    Ophthalmology, Kagawa Univ Faculty of Medicine, Kita-gun, Japan
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 3155. doi:
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      Kazuyuki Hirooka, Tetsuya Baba, Eri Nitta, Kaori Tenkumo, Shino Sato; Preoperative intravitreal bevacizumab on trabeculectomy with mitomycin C for neovascular glaucoma: prognostic factor for surgical failure. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3155.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To evaluate the prognostic factors for surgical outcomes of intravitreal bavacizumab (IVB) before mitomycin C trabeculectomy for neovascular glaucoma (NVG).

Methods: This study is a retrospective, consecutive case series. We reviewed the medical records of 80 patients (80 eyes) with NVG treated at Kagawa University Hospital. The primary endpoint was persistent intraocular pressure (IOP) > 21 mmHg, deterioration of visual acuity to no light perception, and additional glaucoma surgeries. The following variables were assessed as potential prognostic factors for surgical failure: age, etiology of NVG, preoperative IOP, peripheral anterior synechiae (PAS), previous vitrectomy, and previous cataract surgery. Multivariate analysis was performed using the Cox proportional hazard model.

Results: The mean follow-up period was 27.0 months (range, 2 to 77 months). The probability of success 1 and 2 years after trabeculectomy was 87.5% and 81.1%, respectively. In total, 12 of 80 patients were classified as surgical failure. The multivariate model showed that there was no prognostic factor for surgical failure among all NVG patients.

Conclusions: There was no prognostic factor for surgical failure of IVB before mitomycin C trabeculectomy for NVG in all NVG patients.

Keywords: 568 intraocular pressure • 609 neovascularization • 765 wound healing  
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