April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
An ethylcellulose spacer is similar to mitomycin C in prolonging bleb survival in an experimental animal model
Author Affiliations & Notes
  • Alastair Lockwood
    National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom
    UCL School of Pharmacy, London, United Kingdom
  • Abeer Mohamed Ahmed
    National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom
    UCL School of Pharmacy, London, United Kingdom
  • Ashkan Khalili
    National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom
    UCL School of Pharmacy, London, United Kingdom
  • Sahar Awwad
    National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom
    UCL School of Pharmacy, London, United Kingdom
  • Garima Sharma
    National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom
    UCL School of Pharmacy, London, United Kingdom
  • Athmar Dhahir Habeeb
    National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom
    UCL School of Pharmacy, London, United Kingdom
  • Hanieh Khalili
    National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom
    UCL School of Pharmacy, London, United Kingdom
  • Steve Brocchini
    National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom
    UCL School of Pharmacy, London, United Kingdom
  • Peng Khaw
    National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom
  • Footnotes
    Commercial Relationships Alastair Lockwood, None; Abeer Mohamed Ahmed, None; Ashkan Khalili, None; Sahar Awwad, None; Garima Sharma, None; Athmar Habeeb, None; Hanieh Khalili, None; Steve Brocchini, WO09/063222 (P); Peng Khaw, WO09/063222 (P)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 3202. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Alastair Lockwood, Abeer Mohamed Ahmed, Ashkan Khalili, Sahar Awwad, Garima Sharma, Athmar Dhahir Habeeb, Hanieh Khalili, Steve Brocchini, Peng Khaw; An ethylcellulose spacer is similar to mitomycin C in prolonging bleb survival in an experimental animal model. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3202.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract 
 
Purpose
 

The application of an inert spacer is a potential non-toxic alternative to mitomycin C (MMC) for prolonging bleb survival in glaucoma surgery, and the principal by which drainage devices succeed. The aim of this experiment was to compare bleb survival using a small diameter implant with MMC.

 
Methods
 

A randomised, prospective, masked, single observer in vivo study over 30 days. Glaucoma filtration surgery was performed on 14 New Zealand White rabbits. The rabbits received perioperatively one of two potential subconjunctival treatments, randomised according to a Latin Square design: MMC solution (0.2 mg for 3 minutes) or ethylcellulose tablet 2 mm diameter X 0.4 mm high (1 mg). Success was determined according to bleb survival.

 
Results
 

Of the MMC treated group, 29% (2) had successful blebs at day 30, and of the ethylcellulose treated group 43 % (3) had successful blebs at day 30. The differences in bleb survival between the ethylcellulose tablets and MMC were not statistically significant (log rank P = 0.57).

 
Conclusions
 

An inert implant appears to promote bleb survival to a similar extent to MMC in this animal model using masked observer standard measurements of failure. The spacer effect may have an important effect in this model and this may also be clinically relevant in the development of new therapies and devices for glaucoma surgery.

 
 
Placement of ethylcellulose spacer at time of surgery
 
Placement of ethylcellulose spacer at time of surgery
 
 
Survival curves of ethylcellulose spacer and mitomycin C treatment arms.
 
Survival curves of ethylcellulose spacer and mitomycin C treatment arms.
 
Keywords: 474 conjunctiva • 765 wound healing • 427 aqueous  
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×