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Kuniharu Tasaki, Fumiki Okamoto, Yoshimi Sugiura, Yoshifumi Okamoto, Tetsuro Oshika; Aniseikonia and Foveal Microstructure Following Vitrectomy for Epiretinal Membrane. Invest. Ophthalmol. Vis. Sci. 2014;55(13):326. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To quantify the degree of aniseikonia in patients undergoing vitrectomy for epiretinal membrane (ERM), and to investigate the relationship between aniseikonia and foveal microstructures with spectral-domain optical coherence tomography (SD-OCT).
This study included 44 eyes of 44 patients with idiopathic ERM. We examined visual acuity and aniseikonia with the New Aniseikonia Test and SD-OCT before and 3and 6 months after surgery. Based on the obtained OCT images, we quantified the following parameters using an image-processing program: central foveal thickness (CFT), mean thickness of the ganglion cell layer (GCL), inner nuclear layer (INL) and outer retinal layer (ONL+OPL: outer nuclear layer and outer plexiform layer). The status of the photoreceptor inner and outer segment junction (IS/OS), external limiting membrane (ELM), and cone outer segment tips (COST) were also evaluated.
Thirty-nine of 44 patients (89%) had macropsia, 1 patient (2%) had micropsia, and 4 patients (9%) had no aniseikonia preoperatively. Mean preoperative aniseikonia score was 6.1 ± 4.7%. Vitrectomy significantly improved visual acuity in patients with ERM, but did not change the severity of aniseikonia. Multiple regression analysis revealed that preoperative aniseikonia was significantly related to preoperative INL thickness, while postoperative aniseikonia was associated with postoperative INL thickness. Preoperative INL thickness was found to be a significant prognostic factor for postoperative aniseikonia at 6 months.
Most of the ERM patients had macropsia, which did not improve by surgery. The severity of aniseikonia was associated with preoperative INL thickness.
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