April 2014
Volume 55, Issue 13
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ARVO Annual Meeting Abstract  |   April 2014
Evaluation of retinal architecture in glaucoma patients using spectral-domain optical coherence tomography
Kathleen Ellen Guinn; Nithya Rajagopalan; Peter Bracha; Mohammad Ali Sadiq; Jose Maya; Mohamed Ibraheem; Sushma Rai; Vikas Gulati; Quan Dong Nguyen; Yasir Sepah
Author Affiliations & Notes
  • Kathleen Ellen Guinn
    Ocular Imaging Research and Reading Center, Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE
  • Nithya Rajagopalan
    Ocular Imaging Research and Reading Center, Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE
  • Peter Bracha
    Ocular Imaging Research and Reading Center, Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE
  • Mohammad Ali Sadiq
    Ocular Imaging Research and Reading Center, Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE
  • Jose Maya
    Ocular Imaging Research and Reading Center, Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE
  • Mohamed Ibraheem
    Ocular Imaging Research and Reading Center, Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE
  • Sushma Rai
    Ocular Imaging Research and Reading Center, Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE
  • Vikas Gulati
    Ocular Imaging Research and Reading Center, Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE
  • Quan Dong Nguyen
    Ocular Imaging Research and Reading Center, Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE
  • Yasir Sepah
    Ocular Imaging Research and Reading Center, Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE
  • Footnotes
    Commercial Relationships Kathleen Guinn, None; Nithya Rajagopalan, None; Peter Bracha, None; Mohammad Sadiq, None; Jose Maya, None; Mohamed Ibraheem, None; Sushma Rai, None; Vikas Gulati, None; Quan Dong Nguyen, Genentech (F); Yasir Sepah, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 333. doi:
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      Kathleen Ellen Guinn, Nithya Rajagopalan, Peter Bracha, Mohammad Ali Sadiq, Jose Maya, Mohamed Ibraheem, Sushma Rai, Vikas Gulati, Quan Dong Nguyen, Yasir Sepah; Evaluation of retinal architecture in glaucoma patients using spectral-domain optical coherence tomography. Invest. Ophthalmol. Vis. Sci. 2014;55(13):333.

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Abstract
 
Purpose
 

To examine the thickness of retinal layers in patients with established diagnosis of glaucoma compared to a normative database.

 
Methods
 

Spectral-domain optical coherence tomography (SD-OCT) images were acquired for 36 eyes (24 consecutive patients) with known diagnosis of glaucoma and no known macular disease. Horizontal B-scans passing through the fovea were then segmented using Heyex v.5.2 software; retinal thickness was recorded for each layer. Layers were measured every 0.5 mm; an average of temporal, central, and nasal regions was taken. Various layers included: full retinal thickness (FRT), photoreceptor layer (PRL), bipolar layer (BPL), retinal pigment epithelium (RPE), nerve fiber layer (NFL), ganglion cell layer and inner plexiform layer (GCL+). These measured values were then compared to a database of 51 eyes with no known disease. Humphrey visual field (obtained on same day as OCT) results were also correlated to the retinal thicknesses of each layer.

 
Results
 

Mean age of glaucoma subjects was 61 while mean age of normals was 52. Twelve (50%) patients were male while 26 (51%) normals were male. FRT, BP, GCL+ and NFL/GCL+ complex showed significant thinning in all regions of the fovea. The PRL showed significant thinning in the central and temporal zones only. Conversely, the NFL showed significant thinning only in the central and nasal regions. The RPE showed no significant thinning in any region. VFI showed a decreasing trend with the loss of both FRT and individual retinal layers.

 
Conclusions
 

Overall, eyes with glaucoma demonstrate thinning in various retinal layers. In particular, this study has shown for the first time that thinning of the BPL in all foveal regions and PRL in the central and temporal regions occurs in glaucomatous eyes. In addition, VFI appears to correlate with retinal thickness.

 
Table 1. Mean thickness values for various retinal layers in central, temporal and nasal foveal regions. p-values were from two-tailed, homoscedastic t-tests.
View OriginalDownload Slide
 
Table 1. Mean thickness values for various retinal layers in central, temporal and nasal foveal regions. p-values were from two-tailed, homoscedastic t-tests.
 
Table 1. Mean thickness values for various retinal layers in central, temporal and nasal foveal regions. p-values were from two-tailed, homoscedastic t-tests.
Table 1. Mean thickness values for various retinal layers in central, temporal and nasal foveal regions. p-values were from two-tailed, homoscedastic t-tests.
View OriginalDownload Slide
 
Keywords: 550 imaging/image analysis: clinical • 691 retina: proximal (bipolar, amacrine, and ganglion cells) • 758 visual fields  
© 2014, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2015 Association for Research in Vision and Ophthalmology.
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