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Seungsoo Rho, Caleb Jee Hyun Park, Youngje Sung, Won Kyung Song, Saeheun Rho, Hyoung Won Bae, Sang Yeop Lee, Chan Yun Kim; Correlation between the Position of Retinal Nerve Fiber Layer Peak and the Position of Retinal Major Vessels in Healthy Korean Eyes.. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3361.
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We hypothesized that the location of retinal major arteries and veins can affect the location of retinal nerve fiber layer (RNFL) peak. We sought to assess the correlation between the position of the retinal major vessel and the position of the RNFL peak.
The RNFL scans of 52 healthy eyes were enrolled in the study. The average RNFL thickness profiles were obtained using Fourier domain optical coherence tomography (FD-OCT). The location data of RNFL peak were compared to those of major arteries and veins. Superotemporal RNFL peaks (STp) and inferotemporal RNFL peaks (ITp) were assessed with superotemporal major vessels (artery (STa), vein (STv)) and inferotemporal major vessels (artery (ITa), vein (ITv)), respectively. Pearson’s correlation coefficient was used to assess the correlation between the variables, and then a regression equation was formulated using a least square method.
The mean age of the participants were 53.56 ± 10.47 years old. The mean locations of STp and ITp were 76.49 ± 14.08 degree and 290.52 ± 11.25 degree, respectively. STp was more correlated with STa (r=0.819, p<0.001) than STv (r=0.223, p=0.112). ITp was more correlated with ITa (r=0.555, p<0.001) than ITv (r=0.409, p=0.003). According to the extracted regression equation, axial length and the peak position of artery are the key factors determining the peak position of RNFL thickness (adjusted R square = 0.693) in a multiple regression analysis.
In both superotemporal and inferotemporal area, the location of artery is correlated to each RNFL peak. The consideration of major vessel location might be helpful for improving the accuracy of glaucoma detection.
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