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Sonia Valsero Franco, Sergio Pinar, Joseba Artaraz, Beatriz Jiménez Gómez, Maria Elena Gonzalez-Montpetit, Ana Orive, Alex Fonollosa; Functional and structural outcomes in the Posner-Schlossman syndrome. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3396.
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Posner-Schlosman syndrome had been classicaly considered a benign uveitic condition. However, some recent papers and our own clinical experience have shown that glaucoma may be a relatively frequent complication in these patients. The aim of our study was to describe the clinical characteristics and the functional and OCT-related structural outcomes in patients with Posner-Schlossman syndrome.
Cross sectional study of patients with Posner-Schlossman syndrome diagnosed at Cruces University Hospital. Variables recorded: age, gender, follow-up, number of previous attacks, mean intraocular pressure during attacks, CMV infection, damage in retinal nerve fibers layer and ganglion cells layer assessed by OCT and visual field abnormalities assessed by Humphrey visual field perimeter (24-2). Statistics: Mann Whitney U test. The level of statistical significance was set at p<0.05.
22 eyes of 21 patients (15 men, 6 women) were included. Mean age: 37,44±9,3. Follow-up: 60 months [5-360], number of previous attacks: 4 [1-20], mean intraocular pressure during attacks: 39 ± 7 mm Hg. 17% needed surgery to control intraocular pressure. Five out of 13 patients in which an aqueous humour tap was performed were positive for CMV (PCR). Frequency of glaucomatous defects in affected eyes was 62% versus 35% in non affected. Regarding OCT results, we did not find statistical significant differences between affected and non affected eyes: Retinal Nerve Fiber Layer Thickness (83,25 versus 88,21 micron, p=0,33) and average Ganglion Cell Layer thickness (75,6 versus 81,05 micron p=0,32). CMV positive affected eyes presented worse structural outcomes regarding Retinal Nerve Fiber Layer Thickness (67 versus 89,62 microns p=0.016) and Ganglion Cell Layer thickness (56,80 versus 81,5 microns, p= 0,019) than CMV negative.
Patients with Posner-Schlossman syndrome presented visual field abnormalities in affected eyes frequently. We have not observed significant differences in OCT parameters when comparing affected and non affected eyes. CMV positive eyes may present worse structural outcomes than CMV negative eyes.
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