April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Angiographic and Tomographic Characterization of Intermediate Age-related Macular Degeneration
Author Affiliations & Notes
  • Ga Eun Cho
    Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
  • Se Woong Kang
    Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
  • Song Ee Chung
    Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
  • Sang Jin Kim
    Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
  • Jae Hui Kim
    Ophthalmology, Kim’s Eye Hospital, Myung-Gok Eye Research Institute, Konyang University College of Medicine, Seoul, Republic of Korea
  • Mingui Kong
    Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 3404. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Ga Eun Cho, Se Woong Kang, Song Ee Chung, Sang Jin Kim, Jae Hui Kim, Mingui Kong; Angiographic and Tomographic Characterization of Intermediate Age-related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3404.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract
 
Purpose
 

To characterize the eyes with both choroidal thickening and hyperpermeability in subjects diagnosed with bilateral intermediate age-related macular degeneration (AMD).

 
Methods
 

We included 102 Korean patients with bilateral intermediate AMD, 15 patients with unilateral exudative AMD, 15 patients with unilateral polypoidal choroidal vasculopathy (PCV), and 15 patients with unilateral active central serous chorioretinopathy (CSC) in this cross-sectional observational study. Intermediate AMD was defined in accordance with Age-Related Eye Disease Study (AREDS) criteria. Eyes of bilateral intermediate AMD were categorized by the presence of choroidal hyperpermeability and the mean subfoveal choroidal thickness (SFCT). Those (group B) with both choroidal hyperpermeability and above-mean SFCT were compared with the rest of eyes (group A), regarding the demographic, tomographic and angiographic variables. In addition, group B was compared with unaffected fellow eyes of unilateral exudative AMD, PCV, and CSC, which manifested subretinal or sub-retinal pigment epithelial deposits (SD), classifiable as AREDS category 3 intermediate AMD (three representative diagnostic groups).

 
Results
 

There were 70 eyes (34.3%) of 38 patients with both above-average SFCT and choroidal hyperpermeability (group B). Compared with group A, group B patients tended to be younger (66.3 ± 9.3 years vs. 59.1 ± 7.1 years, p <0.001) and showed male preponderance (35.9 % vs. 71.8 %, p = 0.002). In group B, SDs were larger (p = 0.010) and had relatively non-circular margin (p = 0.003), asymmetric distribution (p = 0.012), pigment abnormality more frequently (p = 0.042) on funduscopy. Eyes in group B were also more frequently accompanied by pathologic tomographic findings (p = 0.012) and choroidal filling delay (p = 0.001), compared with those of group A. There was marked similarities in the characteristics of SD, choroidal thickness profile, and demography between group B and the fellow eyes of unilateral CSC.

 
Conclusions
 

These results suggest that about a third of eyes diagnosed as intermediate AMD by funduscopy may constitute different disease characteristics from the majority of such cases in the Asian population. The tomographic and angiographic features suggest these lesions to possibly be a form of chronic inactive CSC.

 
Keywords: 412 age-related macular degeneration  
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×