April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Grey hyper-reflective subretinal exudative lesions in wet age-related macular degeneration
Author Affiliations & Notes
  • Raphaelle Ores
    Ophtalmology, Centre Hospitalier Intercommunal de Creteil, Creteil, France
  • Nathalie Puche
    Ophtalmology, Centre Hospitalier Intercommunal de Creteil, Creteil, France
  • Giuseppe Querques
    Ophtalmology, Centre Hospitalier Intercommunal de Creteil, Creteil, France
  • Rocio Blanco-Garavito
    Ophtalmology, Centre Hospitalier Intercommunal de Creteil, Creteil, France
  • Benedicte Merle
    Ophtalmology, Centre Hospitalier Intercommunal de Creteil, Creteil, France
  • Gabriel J Coscas
    Ophtalmology, Centre Hospitalier Intercommunal de Creteil, Creteil, France
  • Hassiba Oubraham
    Ophtalmology, Centre Hospitalier Intercommunal de Creteil, Creteil, France
  • Oudy Semoun
    Ophtalmology, Centre Hospitalier Intercommunal de Creteil, Creteil, France
  • Eric H Souied
    Ophtalmology, Centre Hospitalier Intercommunal de Creteil, Creteil, France
  • Footnotes
    Commercial Relationships Raphaelle Ores, None; Nathalie Puche, None; Giuseppe Querques, Novartis (C); Rocio Blanco-Garavito, None; Benedicte Merle, None; Gabriel Coscas, Novartis (C); Hassiba Oubraham, None; Oudy Semoun, None; Eric Souied, Novartis (C)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 3406. doi:
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      Raphaelle Ores, Nathalie Puche, Giuseppe Querques, Rocio Blanco-Garavito, Benedicte Merle, Gabriel J Coscas, Hassiba Oubraham, Oudy Semoun, Eric H Souied; Grey hyper-reflective subretinal exudative lesions in wet age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3406.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract 
 
Purpose
 

To investigate the effects of ranibizumab 0.5 mg on grey hyper-reflective subretinal lesions (GHSL) diagnosed by spectral domain optical coherence tomography (SD-OCT) in patients with exudative age-related macular degeneration (AMD).

 
Methods
 

Retrospective study. Data from 28 consecutive patients affected with neovascular AMD that presented subretinal hyper-reflective lesions as visualized by SD-OCT were collected. GHSL characteristics were analyzed, before and after intravitreal ranibizumab 0.5 mg injection.

 
Results
 

Thirty eyes of 28 patients (5 male, 23 female, aged 57-91 years) were included. At study entry, GHSL was associated with exudative features in 24/30 eyes (80%), including subretinal fluid (SRF) in 20/30 of eyes (67%), and retinal cysts in 11/30 of eyes (37%). Twenty-four eyes with exudative features at study entry received prompt treatment; 6 eyes without exudative features at study entry received deferred treatment (after one-month observation), when exudative signs emerged (SRF in 3/6 eyes and retinal cysts in 5/6 eyes). Ninety-three percent of the GHSL responded to ranibizumab treatment. GHSL thickness was significantly reduced (from 482±116μm to 367±102μm, p<0.0001) after treatment.

 
Conclusions
 

Our findings suggest that GHSL might be considered as qualitative criteria for retreatment of exudative AMD. It may represent an early sign of active CNV, and should prompt to early treatment.

 
 
Spectral domain Optical coherence tomography (SD-OCT) follow up of grey hyper-reflective subretinal lesions before and after treatment. SD-OCT images. Each horizontal line corresponds to one patient. Right pannels correspond to SD-OCT before treatement and left pannels to SD-OCT after treatment. Grey hyper-reflective subretinal lesions (GHSL) are underlined by arrows and exudative signs by stars. Note the total regression of both GHSL and exudative signs for almost all patients
 
Spectral domain Optical coherence tomography (SD-OCT) follow up of grey hyper-reflective subretinal lesions before and after treatment. SD-OCT images. Each horizontal line corresponds to one patient. Right pannels correspond to SD-OCT before treatement and left pannels to SD-OCT after treatment. Grey hyper-reflective subretinal lesions (GHSL) are underlined by arrows and exudative signs by stars. Note the total regression of both GHSL and exudative signs for almost all patients
 
Keywords: 412 age-related macular degeneration • 550 imaging/image analysis: clinical  
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