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Akihiro Ishibazawa, Taiji Nagaoka, Yoshiro Minami, Akitoshi Yoshida; ASSESSMENT OF CHOROIDAL THICKNESS BEFORE AND AFTER HEMODIALYSIS IN PATIENTS WITH AND WITHOUT DIABETES. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3417.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the effect of hemodialysis (HD) on the choroidal thickness in patients with and without diabetes who have end-stage kidney disease (ESKD).
Forty-four patients with ESKD were recruited and divided into two groups: those with ESKD due to diabetic nephropathy (DM group, 33 eyes of 18 patients) and those with non-diabetic ESKD (NDM group, 50 eyes of 26 patients). Using optical coherence tomography, the subfoveal choroidal thickness (SCT) was measured before and after HD, and the change ratio (ΔSCT [expressed as %]) was evaluated. The relations between the right and left ΔSCT values and those between the ΔSCT (value from one eye was selected) and body fluid removal (BFR [expressed in mL]) were assessed.
The SCT decreased in all eyes after HD. In the DM group, the mean SCT values before and after HD were 268 ± 78 μm and 234 ± 72 μm, respectively. In the NDM group, the mean SCT values were 251 ± 81 μm and 235 ± 77 μm, respectively. The mean ΔSCT values in the DM and NDM groups were -13.1 ± 3.5% and -6.8 ± 2.4%, respectively; the decrease in the SCT in the DM group was significantly (p < 0.001) greater than that in the NDM group. The relations between the right and left ΔSCT values were significant in the DM group (R2 = 0.31, p < 0.05) and the NDM group (R2 = 0.68, p < 0.001). The relation between the ΔSCT and BFR was not significant (R2 = 0.002, p = 0.43) in the DM group but was significant (R2 = 0.69, p < 0.001) in the NDM group.
The SCT decreased after HD, and the change in choroidal thickness after HD was larger in the patients with DM than that in the patients without DM. The results suggest that the systemic overflow of bodily fluid is affected more in the choroid in patients with DM.
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