April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
MULTIPLE SCLEROSIS AND NEUROMYELITIS OPTICA: ANALYSIS OF MULTIFOCAL VISUAL EVOKED POTENTIALS
Author Affiliations & Notes
  • Gustavo Meireles Amorim
    Nucleo de Medicina Tropical, Universidade Federal do Para, Belem, Brazil
    Institudo de Ciencias da Saude, Universidade Federal do Para, Belem, Brazil
  • Lucas Daniel Almeida Fernandes
    Nucleo de Medicina Tropical, Universidade Federal do Para, Belem, Brazil
    Institudo de Ciencias da Saude, Universidade Federal do Para, Belem, Brazil
  • Lorena Botelho Vergara
    Nucleo de Medicina Tropical, Universidade Federal do Para, Belem, Brazil
    Institudo de Ciencias da Saude, Universidade Federal do Para, Belem, Brazil
  • Phelipe Augusto Rabelo Paixao
    Nucleo de Medicina Tropical, Universidade Federal do Para, Belem, Brazil
    Institudo de Ciencias da Saude, Universidade Federal do Para, Belem, Brazil
  • Raisa L dos Santos
    Nucleo de Medicina Tropical, Universidade Federal do Para, Belem, Brazil
    Institudo de Ciencias da Saude, Universidade Federal do Para, Belem, Brazil
  • Patrick Lopes
    Nucleo de Medicina Tropical, Universidade Federal do Para, Belem, Brazil
    Institudo de Ciencias da Saude, Universidade Federal do Para, Belem, Brazil
  • Eliza M C B Lacerda
    Nucleo de Medicina Tropical, Universidade Federal do Para, Belem, Brazil
    Instituto de Ciencias Biologicas, Universidade Federal do Para, Belem, Brazil
  • Givago S Souza
    Nucleo de Medicina Tropical, Universidade Federal do Para, Belem, Brazil
    Instituto de Ciencias Biologicas, Universidade Federal do Para, Belem, Brazil
  • Alexandre Rosa
    Institudo de Ciencias da Saude, Universidade Federal do Para, Belem, Brazil
    Hospital Universitario Bettina Ferro de Souza, Universidade Federal do Para, Belem, Brazil
  • Luiz Carlos L Silveira
    Nucleo de Medicina Tropical, Universidade Federal do Para, Belem, Brazil
    Instituto de Ciencias Biologicas, Universidade Federal do Para, Belem, Brazil
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 344. doi:
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      Gustavo Meireles Amorim, Lucas Daniel Almeida Fernandes, Lorena Botelho Vergara, Phelipe Augusto Rabelo Paixao, Raisa L dos Santos, Patrick Lopes, Eliza M C B Lacerda, Givago S Souza, Alexandre Rosa, Luiz Carlos L Silveira; MULTIPLE SCLEROSIS AND NEUROMYELITIS OPTICA: ANALYSIS OF MULTIFOCAL VISUAL EVOKED POTENTIALS. Invest. Ophthalmol. Vis. Sci. 2014;55(13):344.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To compare the reliability indexes multifocal visual evoked potentials (mfVEP) in patients with multiple sclerosis (MS) and neuromyelitis optica (NMO).

Methods: Patients with multiple sclerosis (9 subjects, 18 eyes, 37 ± 9.7 years old) and NMO (12 subjects, 20 eyes, 36.1 ± 11.8 years old) were studied by biomicroscopy, fundoscopy, visual acuity and visual electrophysiology (mfVEP). mfVEP was recorded using Veris 6010 system with 60 sectors black and white. We estimated the signal-to-noise ratio (SNR) for each form of mfVEP wave. The mfVEP waveforms were reliable when the SNR was greater than 1.395. Moreover , the rates of reliable forms of wave mfVEP was quantified as the ratio between the number of waveforms confidence / total number of sectors of six areas of the same eccentricity (from inside the visual field R1 to R6 in exterior visual field ) and the whole visual field. We used the binomial test, α = 0.05 as analysis.

Results: Optic neuritis (ON) was present in 5/18 eyes of patients with multiple sclerosis and 9/ 20 patients NMO. Confidence indices of mfVEP for the controls were higher than for the MS with or without ON and NMO with ON in R1 - R5. In R6, the control rate was higher than the rate for all other groups of patients. The rate of mfVEP to reliably controls were higher than those obtained for the MS and ON with or without NMO MS (p < 0.01) in R1 - R5. In R6, the control rate was higher than the rate for all other groups of patients. The rate of mfVEP reliable for NMO group was higher than the rate of set of MS, despite the presence of NO. The rate waveform to trust the MS group without ON was higher than for the MS group with ON (p<0.01), and there was no difference between NMO group with and without ON for all analyzed areas.

Conclusions: The rate of reliability mfVEP wave was the lowest among MS patients and the presence of ON significantly decreased the performance of patients with MS and NMO ways to generate reliable mfVEP wave.

Keywords: 507 electrophysiology: clinical • 613 neuro-ophthalmology: optic nerve • 629 optic nerve  
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