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Pinakin Gunvant Davey, F. Carusone, S. Alvarez, P. Vyas, Jack Greenan, T. Thamsopit, S. Zaczyk, R. Shah, C. Lievens; Association of Macular Pigment Optical Density (MPOD) and age in ocular healthy adults of different ethnicities -A preliminary report. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3492.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the effect of age on the macular pigment as assessed by heterochromatic flicker photometry in a group of ocular healthy individuals of various ethnicities.
The macular pigment study group is created to better understand the role of macular pigment in retinal diseases. This cross-sectional study was designed to understand the level of macular pigment optical density (MPOD) at different decades of life. To further asses if the different ethnic groups had different level of macular pigment when compared to each other. The study was conducted at two sites, Pomona California and Memphis, Tennessee. It is aims to recruit 600 qualified ocular healthy subjects; 150 in each ethnicity of Caucasian, African American, Asian Indian and Hispanic. The study began in March 2013 and anticipates completion around March 2015. This interim report summarizes the findings of MPOD measured on the dominant eye of the qualified 264 subjects of; 96 Caucasian, 78 African American, 22 Asian Indian and 68 Hispanic. The mean age of was 38, 43, 28, 39 years for Caucasian, African American, Asian Indian and Hispanic respectively. The mean age of each Asian Indians was significantly lower than the other groups.
The mean MPOD as measured by the heterochromatic flicker photometry was 0.41, 0.39, 0.56 and 0.50 for the groups I, II, III and IV respectively. The mean MPOD was significantly lower in the Caucasian and African American when compared to Asian Indian and Hispanic respectively (One way-ANOVA p<0.0001). There was a trend of lower MPOD with increase in age which did not reach statistical significance overall (r-square 0.005, linear regression p=0.2).
The preliminary analysis indicates that the MPOD may be different in different ethnicities but overall MPOD may remain similar with increase in age. The complete report will shed better light on the effect of age on MPOD in various ethnicities.
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