April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Evaluation of the Unaffected Fellow Eye of Unilateral Exfoliation Syndrome and Exfoliation Glaucoma Eyes using Short Duration Transient Visual Evoked Potentials (SD-tVEP)
Author Affiliations & Notes
  • Lam Lu
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, NY
  • Peter H Derr
    Diopsys Inc., Pine Brook, NY
  • Jessica V Jasien
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, NY
  • Alberto Omar Gonzalez Garcia
    Diopsys Inc., Pine Brook, NY
  • Celso Tello
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, NY
  • Jeffrey M Liebmann
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, NY
    NYU School of Medicine, New York, NY
  • Robert Ritch
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, NY
    New York Medical College, Valhalla, NY
  • Footnotes
    Commercial Relationships Lam Lu, None; Peter Derr, Diopsys (E); Jessica Jasien, None; Alberto Gonzalez Garcia, Diopsys (E); Celso Tello, Diopsys (R); Jeffrey Liebmann, Diopsys (R); Robert Ritch, Diopsys (R)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 3503. doi:https://doi.org/
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      Lam Lu, Peter H Derr, Jessica V Jasien, Alberto Omar Gonzalez Garcia, Celso Tello, Jeffrey M Liebmann, Robert Ritch; Evaluation of the Unaffected Fellow Eye of Unilateral Exfoliation Syndrome and Exfoliation Glaucoma Eyes using Short Duration Transient Visual Evoked Potentials (SD-tVEP). Invest. Ophthalmol. Vis. Sci. 2014;55(13):3503. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To evaluate the fellow eye of unilateral Exfoliation Syndrome (XFS) and Exfoliation Glaucoma (XFG) patients using SD-tVEP.

Methods: The study population was divided into three age-matched groups: 1) 15 randomly selected eyes of 15 healthy subjects (70.2±5.4 yr); 2) 30 eyes of 15 unilateral XFS patients (73.9±6.0 yr); and 3) 26 eyes of 13 unilateral XFG patients (70.5±9.1 yr). SD-tVEP’s were recorded using the Diopsys NOVA System (Diopsys, Inc. Pine Brook, NJ). An area under the curve (AUC) analysis of the SD-tVEP parameters was performed comparing the XFS/XFG eyes and the healthy eyes. 1-way ANOVA was performed on the SD-tVEP parameters to determine if significant differences existed between the XFS/XFG eye and the unaffected fellow eyes; between the XFS and XFG eyes; between the XFS/XFG fellow eye and the healthy eyes; and between the XFS/XFG and the healthy eyes.

Results: No significant difference was found between the XFS/XFG and fellow eye (p=0.43, p=0.21 respectively) under SD-tVEP parameters, nor was one found between the XFS and XFG eyes (p=0.39). In addition, the differences between both XFS/XFG fellow eyes and the healthy eyes approached but were not significant (p=0.054, p=0.06). However, significant differences were found between both XFS/XFG eyes and the healthy eyes (p=0.01, p=0.03 respectively). Comparing the healthy eyes to the XFS/XFG eyes, the AUC for the XFS eyes was Hc P100 amplitude 0.77 (0.58 - 0.96); Hc P100 latency 0.75 (0.56 - 0.93); Lc P100 amplitude 0.71 (0.50 - 0.91); and Lc latency 0.74 (0.56 - 0.93) and the AUC for the XFG eyes was Hc P100 amplitude 0.78 (0.59 - 0.97); Hc P100 latency 0.84 (0.67 - 1.00); Lc P100 amplitude 0.76 (0.57 - 0.95); and Lc latency 0.75 (0.55 - 0.95).

Conclusions: Short-duration transient VEP may be capable of detecting subtle alterations in the uninvolved fellow eye of unilateral XFS/XFG eyes prior to other abnormalities. Further study with a larger number of patients is needed to confirm these preliminary findings.

Keywords: 758 visual fields • 612 neuro-ophthalmology: diagnosis  
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