April 2014
Volume 55, Issue 13
ARVO Annual Meeting Abstract  |   April 2014
Assessment of the Relationship Between Choroidal Thickness and Drusen Burden in Non-neovascular Age-related Macular Degeneration
Author Affiliations & Notes
  • Jaehong Han
    Case Western Reserve University School of Medicine, Cleveland Heights, OH
    Cole Eye Institute, Cleveland Clinic, Cleveland, OH
  • Sumit Sharma
    Cole Eye Institute, Cleveland Clinic, Cleveland, OH
  • Peter K Kaiser
    Cole Eye Institute, Cleveland Clinic, Cleveland, OH
  • Justis P Ehlers
    Cole Eye Institute, Cleveland Clinic, Cleveland, OH
  • Footnotes
    Commercial Relationships Jaehong Han, None; Sumit Sharma, None; Peter Kaiser, Alcon (C), Bausch and Lomb (C), Bayer (C), Carl Zeiss Meditec (C), Genentech (C), Novartis (C), Ophthotech (C), Oraya (C), Regeneron (C), Topcon (C); Justis Ehlers, Bioptigen (I), Regeneron (S), Thrombogenics (C)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 3531. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Jaehong Han, Sumit Sharma, Peter K Kaiser, Justis P Ehlers; Assessment of the Relationship Between Choroidal Thickness and Drusen Burden in Non-neovascular Age-related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3531.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Previous research has suggested that choroidal thinning occurs with increasing age. Age-related choroidal atrophy has been previously described as a clinical entity with significant choroidal thinning and a paucity of drusen that may mimic non-neovascular age-related macular degeneration (NNVAMD) or simply be part of the AMD spectrum. This study was performed to assess the relationship between choroidal thickness and drusen burden in eyes presenting with a clinical diagnosis of NNVAMD.


This is a retrospective, consecutive case series of patients with at least one eye with a clinical diagnosis of NNVAMD as determined by one of two retinal specialists. Imaging was performed using the Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA). Subfoveal choroidal thickness was measured on the high resolution raster or enhanced depth imaging (EDI) scan. The advanced retinal pigment epithelium (RPE) analysis algorithm was utilized to calculate the central 5-mm drusen area and volume. Clinical variables collected included visual acuity, lens status and refraction. Patients were excluded if they had subfoveal geographic atrophy or evidence of any other retinal disorder including: neovascular AMD, prior macular laser therapy, high myopia, uveitis or prior vitreoretinal surgery.


183 eyes from 123 patients were included in the analysis. Mean logMAR visual acuity was 0.129 (Snellen equivalent 20/27) with a mean age of 77 years. Mean central retinal thickness was 221.2 microns, and mean manual subfoveal choroidal thickness was 191.1 microns. Mean drusen area and volume in the 5mm ETDRS circle centered on the fovea was 0.54mm2 and 0.21mm3, respectively Choroidal thickness was negatively correlated with drusen area (r=-.2869, p < 0.001) and drusen volume (r=-.2205, p = 0.0024).


Choroidal thickness appears to be inversely correlated with drusen burden in eyes with non-neovascular age-related macular degeneration in the absence of subfoveal geographic atrophy. The relationship of drusen burden to choroidal thickness deserves further investigation in the pathogenesis of NNVAMD in order to further understand the place of age-related choroidal atrophy in the AMD spectrum.

Keywords: 412 age-related macular degeneration • 550 imaging/image analysis: clinical • 688 retina  

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.