April 2014
Volume 55, Issue 13
ARVO Annual Meeting Abstract  |   April 2014
Longitudinal structure function analysis in reticular pseudodrusen
Author Affiliations & Notes
  • Florian Alten
    University Eye Hosp Muenster, Muenster, Germany
  • Peter Heiduschka
    University Eye Hosp Muenster, Muenster, Germany
  • Christoph Roman Clemens
    University Eye Hosp Muenster, Muenster, Germany
  • Nicole Eter
    University Eye Hosp Muenster, Muenster, Germany
  • Footnotes
    Commercial Relationships Florian Alten, Heidelberg Engineering (C), Novartis (C); Peter Heiduschka, Novartis (R); Christoph Clemens, Bayer (C), Heidelberg Engineering (C), Novartis (C); Nicole Eter, Allergan (C), Bayer (C), Heidelberg Engineering (C), Novartis (C)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 3532. doi:
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      Florian Alten, Peter Heiduschka, Christoph Roman Clemens, Nicole Eter; Longitudinal structure function analysis in reticular pseudodrusen. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3532.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: To describe longitudinal structure function correlations in eyes with progressive reticular pseudodrusen (RPD).

Methods: 13 eyes of 12 patients with exclusively RPD in the posterior pole were included (75.1 Φ 5.7 years). All patients underwent spectral-domain optical coherence tomography (SD-OCT), confocal scanning laser ophthalmoscopy (cSLO) and multifocal electroretinography (mfERG) at baseline and 12-month follow-up. Size of retinal area affected by RPD, number and stages of RPD lesions and choroidal thickness (CT) were quantified at baseline and at follow-up visit. Amplitudes obtained by mfERG in RPD eyes at baseline and follow-up were analysed and correlated to morphologic changes.

Results: The total number of RPD lesions increased from 540 at baseline to 667 at 12-month follow-up. Mean CT was 198.5 Φ 69.3 µm at baseline (control group 263.5 Φ 42.6 µm; p=0.005) and 189.2 Φ 65.3 µm at follow-up (p<0.001) (265 Φ 47.8 µm; p=0.74). A mean growth of RPD-affected area of 3.3 mm2 was measured. mfERG amplitudes decreased in both study and control groups to similar extent. Amplitudes differed significantly at the follow-up time point when compared between RPD-affected and non-affected areas within the same eye. No correlations between changes of morphologic parameters and mfERG amplitude changes were found

Conclusions: mfERG allows for detecting functional changes in RPD-affected eyes over time. Further functional loss due to RPD than detected in our study group presumably occurs at later disease stages, i.e. when RPD regression occurs or outer retinal atrophy develops.

Keywords: 412 age-related macular degeneration • 509 electroretinography: clinical • 504 drusen  

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