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Florian Alten, Peter Heiduschka, Christoph Roman Clemens, Nicole Eter; Longitudinal structure function analysis in reticular pseudodrusen. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3532.
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© ARVO (1962-2015); The Authors (2016-present)
To describe longitudinal structure function correlations in eyes with progressive reticular pseudodrusen (RPD).
13 eyes of 12 patients with exclusively RPD in the posterior pole were included (75.1 Φ 5.7 years). All patients underwent spectral-domain optical coherence tomography (SD-OCT), confocal scanning laser ophthalmoscopy (cSLO) and multifocal electroretinography (mfERG) at baseline and 12-month follow-up. Size of retinal area affected by RPD, number and stages of RPD lesions and choroidal thickness (CT) were quantified at baseline and at follow-up visit. Amplitudes obtained by mfERG in RPD eyes at baseline and follow-up were analysed and correlated to morphologic changes.
The total number of RPD lesions increased from 540 at baseline to 667 at 12-month follow-up. Mean CT was 198.5 Φ 69.3 µm at baseline (control group 263.5 Φ 42.6 µm; p=0.005) and 189.2 Φ 65.3 µm at follow-up (p<0.001) (265 Φ 47.8 µm; p=0.74). A mean growth of RPD-affected area of 3.3 mm2 was measured. mfERG amplitudes decreased in both study and control groups to similar extent. Amplitudes differed significantly at the follow-up time point when compared between RPD-affected and non-affected areas within the same eye. No correlations between changes of morphologic parameters and mfERG amplitude changes were found
mfERG allows for detecting functional changes in RPD-affected eyes over time. Further functional loss due to RPD than detected in our study group presumably occurs at later disease stages, i.e. when RPD regression occurs or outer retinal atrophy develops.
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