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Amir Marvasti, Andrew J Tatham, Linda M Zangwill, Robert N Weinreb, Felipe A Medeiros, Diagnostic Innovations in Glaucoma Study (DIGS); The Relationship between Intraocular Pressure and Rates of Estimated Retinal Ganglion Cell Loss in Glaucoma.. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3551.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the influence of mean intraocular pressure (IOP) during follow up on rates of estimated retinal ganglion cell (RGC) loss in glaucoma.
270 eyes of 178 subjects with glaucoma and suspected glaucoma were followed for mean ± SD of 6.3 ± 2.7 (range: 2.1 to 11.0) years, with an average of 9 ± 3 (range: 5 to 17) visits duri
At baseline, the average SAP mean deviation (MD) was -2.4 ± 3.8 dB and average estimated RGC count was 776,077 ± 230,127 cells. Mean IOP during follow up was 16.8 ± 4.4 mmHg (range: 4.8 to 27.6). Average CCT was 554.1 ± 36.7 μm. There was a significant nonlinear relationship between the estimated rate of RGC loss and mean IOP during follow up with higher IOP associated with a higher rate of RGC loss. In a multivariable model including mean IOP, (mean IOP)^2, CCT, an interaction term CCT*mean IOP, and age at baseline, all variables were significantly associated with rate of RGC loss (P<0.05). Eyes with a mean IOP of 10 mmHg during follow up had estimated RGC losses close to the expected age-related loss of 6,944 cells per year. In contrast, mean IOPs of 16 mmHg, 22 mmHg, and 28 mmHg were associated with losses of 9,869 cells, 17,794 cells, and 30,718 cells per year, respectively (Figure 1).
Higher mean IOP during follow up is associated with greater rates of estimated RGC loss in eyes with glaucoma or suspected glaucoma.
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