April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Transient changes in choroidal thickness to different levels of imposed myopic defocus
Author Affiliations & Notes
  • Jinhua Bao
    School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China
    WEIRC, WMU-Essilor International Research Centre, Wenzhou Medical University, Wenzhou, China
  • Bjorn Drobe
    R&D Optics Asia, Essilor International, Wenzhou, China
    WEIRC, WMU-Essilor International Research Centre, Wenzhou Medical University, Wenzhou, China
  • Ke Chen
    School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China
    WEIRC, WMU-Essilor International Research Centre, Wenzhou Medical University, Wenzhou, China
  • Hao Chen
    School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China
    WEIRC, WMU-Essilor International Research Centre, Wenzhou Medical University, Wenzhou, China
  • Footnotes
    Commercial Relationships Jinhua Bao, Essilor International (F); Bjorn Drobe, Essilor International (F); Ke Chen, Essilor International (F); Hao Chen, Essilor International (F)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 3600. doi:https://doi.org/
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      Jinhua Bao, Bjorn Drobe, Ke Chen, Hao Chen; Transient changes in choroidal thickness to different levels of imposed myopic defocus. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3600. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To investigate short-term changes in choroidal thickness and other ocular biometrics to imposed myopic defocus in young adults.

Methods: Ocular biometrics of thirteen myopic young adult subjects was measured before and after 60 minutes of exposure to monocular defocus (right eye) while watching movies on a 5.5m distant screen. Choroidal and retinal thicknesses were measured by means of Lenstar SD-OCT (Heidelberg Spectralis OCT; Heidelberg Engineering, Heidelberg, Germany) and axial length by Lenstar LS 900 optical biometer (Lenstar LS 900; Haag Streit AG, Koeniz, Switzerland). Four different monocular defocus conditions were tested, each on a separate day: control (no defocus) and myopic defocus (+1D, +3D and +5D defocus). The fellow eye was optimally corrected for distance (no defocus).

Results: After 60 minutes, choroidal thickness of the right eye exhibited a significant increase only for +3D and +5D defocus conditions (mean change, +1D: +7.53±7.80μm, p>0.05; +3D: +12.51±11.23μm, p=0.002; +5D: +11.74±8.45μm, p<0.001). Retinal thickness exhibited no significant change with any myopic defocus conditions (mean change, +1D: -1.17±2.52μm, +3D: -1.93±1.99μm, +5D: -1.77±3.49 μm; p>0.1). Optical axial length decreased significantly only after +5D defocus condition (mean change, +1D: +2.13±9.67μm, p>0.1; +3D: -1.93±9.05μm, p>0.1; +5D: -6.56±9.14μm, p=0.024). Choroidal thickness, retinal thickness and axial length of the left eye showed no significant change (p>0.05).

Conclusions: Significant increase in choroidal thickness occurred in human subjects after 60 minutes of myopic defocus of 3D or more but not in axial length. Moreover, there is no evidence to support the notion that choroidal thickness elongation is proportional to the degree of myopic defocus.

Keywords: 605 myopia • 406 adaptation: blur • 452 choroid  
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