April 2014
Volume 55, Issue 13
ARVO Annual Meeting Abstract  |   April 2014
The Potential of Quercetin for Dry Eye Diseases
Author Affiliations & Notes
  • Takaaki Inaba
    Ophthalmology, Keio University, Shinjyuku-ku, Japan
  • Jun Shimazaki
    Ophthalmology, Tokyo Dental College, ichikawa, Japan
  • Yasuhisa Tanaka
    Ophthalmology, Keio University, Shinjyuku-ku, Japan
  • Kazuo Tsubota
    Ophthalmology, Keio University, Shinjyuku-ku, Japan
  • Footnotes
    Commercial Relationships Takaaki Inaba, None; Jun Shimazaki, None; Yasuhisa Tanaka, None; Kazuo Tsubota, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 3659. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Takaaki Inaba, Jun Shimazaki, Yasuhisa Tanaka, Kazuo Tsubota; The Potential of Quercetin for Dry Eye Diseases. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3659.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Purpose: Prevention of decline in mental and physical functions in the older population has become an important public policy issue in the world. Sensory organs are particularly vulnerable to aging, so that many of eye diseases are closely related to aging. In the course of various studies, anti-oxidizing properties of polyphenol have been gaining medical attention as a preventive factor against aging and/or lifestyle diseases. Quercetin is one of polyphenolic compounds abundantly contained in onions and apples. Much evidence is available on quercetin as a functional food factor particularly for its prominent antioxidant activity among the various polyphenolic compounds. To clarify efficacy of antioxidant activity of quercetin in attenuating pathology of dry eye disease.

Methods: Diabetic model mice were used as decreased tear production model mice. The 6 week-old mice were fed ad libitum with an experimental diet with 0.5% quercetin for 3 months. Total food intake, body weight, and tear volume were measured periodically. Blood biochemical tests and histopathological analysis were conducted upon euthanasia after 3 months of feeding.

Results: As a result of feeding the experimental diet with 0.5% quercetin to the decreased tear production model mice, no changes in the body weight and food intake were observed; however, the decrease of tear volume in the diabetic mice was significantly recovered. Further, changes in the lacrimal gland morphology and the blood chemical values indicated improvements in the pathological features.

Conclusions: Elucidating the association between the antioxidant effects of quercetin and tear secretion is crucial for preventing and/or treating dry eye disease, as it is assumed to be increasingly prevalent as well as lifestyle diseases.

Keywords: 486 cornea: tears/tear film/dry eye  

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.