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Varona Sargent, Mariela C Aguilar, Yoh Sawatari, Alex Gonzalez, William Lee, Cornelis Rowaan, Darlene Miller, Victor L Perez, Eduardo C Alfonso, Jean-Marie A Parel; Long-term static force testing on three MOOKP bonding agents during traumatic ocular simulation: 2-year results. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3737.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the prolonged efficacy of three bonding agents for the potential use in the Modified Osteo-odonto Keratoprosthesis (MOOKP) procedure. The optical cylinder faces were bonded to the osteo-odonto laminas and subjected to high static pressures in order to simulate traumatic ocular occurrences.
In order to simulate the procedure used to generate the osteo-odonto lamina for the MOOKP, 12 extracted canine teeth were used. Each tooth was reduced, contoured, and a hole was drilled to insert the optical cylinder. Four osteo-odonto laminas were generated per bonding agent: Histoacyl (B Braun, TiisueSeal LLC, Ann Arbor, MI), Jet acrylic (Lang Dental Manufacturing Co., Wheeling, IL), and Surgical Simplex P (Stryker, Howmedica Osteonics, Mahwah, NJ). These 12 specimens were conserved in a solution containing BSS, antibiotic (Gatifloxacin 2ug/cc), and antifungal (Amphotericin B 0.2mg/cc) at 36°C were refreshed every month. An instrument was developed to stabilize and simulate traumatic ocular incidents by applying direct forces varying from: 200g - 3kg.
The specimens were tested using a static force of 200g, 500g, and 1kg for 12 months; no changes in the static strength of the 12 laminas were seen. During a 24-month continuation period there was an increment in the force applied of 2 and 3 kg followed by an increased pressure of 30kg/cm2 corresponding to an IOP of 600mmHg. All 12 specimens resisted optical cylinder displacement at all pressures and no difference in the conformation of the lamina and cylinder was observed.
During our 24-month investigation, there was no significant difference seen in the effectiveness of the three MOOKP bonding agents. All three bonding agents tolerated a static force of up to 3kg and a combined pressure of 30kg/cm2. Dynamic force is yet to be tested. Acknowledgments: The authors would like to acknowledge Giancarlo Falcinelli and Andres Bernal for their scientific contributions.
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