April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Long-term static force testing on three MOOKP bonding agents during traumatic ocular simulation: 2-year results
Varona Sargent; Mariela C Aguilar; Yoh Sawatari; Alex Gonzalez; William Lee; Cornelis Rowaan; Darlene Miller; Victor L Perez; Eduardo C Alfonso; Jean-Marie A Parel
Author Affiliations & Notes
  • Varona Sargent
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
  • Mariela C Aguilar
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
  • Yoh Sawatari
    Anne Bates Leach Eye Hospital, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
    Oral Maxillofacial Division, Department of Surgery, University of Miami Miller School of Medicine, Miami, FL
  • Alex Gonzalez
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
  • William Lee
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
  • Cornelis Rowaan
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
  • Darlene Miller
    Anne Bates Leach Eye Hospital, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
    Ocular Microbiology Laboratory, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
  • Victor L Perez
    Anne Bates Leach Eye Hospital, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
  • Eduardo C Alfonso
    Anne Bates Leach Eye Hospital, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
  • Jean-Marie A Parel
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
    Vision Cooperative Research Centre, Brien Holden Vision Institute, UNSW, Sydney, NSW, Australia
  • Footnotes
    Commercial Relationships Varona Sargent, None; Mariela Aguilar, None; Yoh Sawatari, None; Alex Gonzalez, None; William Lee, None; Cornelis Rowaan, None; Darlene Miller, None; Victor Perez, None; Eduardo Alfonso, None; Jean-Marie Parel, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 3737. doi:
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      Varona Sargent, Mariela C Aguilar, Yoh Sawatari, Alex Gonzalez, William Lee, Cornelis Rowaan, Darlene Miller, Victor L Perez, Eduardo C Alfonso, Jean-Marie A Parel; Long-term static force testing on three MOOKP bonding agents during traumatic ocular simulation: 2-year results. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3737.

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Abstract

Purpose: To evaluate the prolonged efficacy of three bonding agents for the potential use in the Modified Osteo-odonto Keratoprosthesis (MOOKP) procedure. The optical cylinder faces were bonded to the osteo-odonto laminas and subjected to high static pressures in order to simulate traumatic ocular occurrences.

Methods: In order to simulate the procedure used to generate the osteo-odonto lamina for the MOOKP, 12 extracted canine teeth were used. Each tooth was reduced, contoured, and a hole was drilled to insert the optical cylinder. Four osteo-odonto laminas were generated per bonding agent: Histoacyl (B Braun, TiisueSeal LLC, Ann Arbor, MI), Jet acrylic (Lang Dental Manufacturing Co., Wheeling, IL), and Surgical Simplex P (Stryker, Howmedica Osteonics, Mahwah, NJ). These 12 specimens were conserved in a solution containing BSS, antibiotic (Gatifloxacin 2ug/cc), and antifungal (Amphotericin B 0.2mg/cc) at 36°C were refreshed every month. An instrument was developed to stabilize and simulate traumatic ocular incidents by applying direct forces varying from: 200g - 3kg.

Results: The specimens were tested using a static force of 200g, 500g, and 1kg for 12 months; no changes in the static strength of the 12 laminas were seen. During a 24-month continuation period there was an increment in the force applied of 2 and 3 kg followed by an increased pressure of 30kg/cm2 corresponding to an IOP of 600mmHg. All 12 specimens resisted optical cylinder displacement at all pressures and no difference in the conformation of the lamina and cylinder was observed.

Conclusions: During our 24-month investigation, there was no significant difference seen in the effectiveness of the three MOOKP bonding agents. All three bonding agents tolerated a static force of up to 3kg and a combined pressure of 30kg/cm2. Dynamic force is yet to be tested. Acknowledgments: The authors would like to acknowledge Giancarlo Falcinelli and Andres Bernal for their scientific contributions.

Keywords: 575 keratoprostheses  
© 2014, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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