Association of LOXL1 polymorphisms with glaucoma risk in subjects with pseudoexfoliation: a meta-analysis

Abstract

Purpose: To conduct a meta-analysis of the association of LOXL1 single nucleotide polymorphisms with glaucoma risk in subjects with pseudoexfoliation (PEX), in Caucasians.

Methods: Association studies were retrieved from PubMed, Embase and Web of Knowledge, using 10 July 2013 as cut-off date. Eligibility criteria were applied and data were extracted by two independent investigators. Allelic distributions and genotype frequencies of rs1048661 (R141L), rs3825942 (G153D), and rs2165241 were compared between subjects with PEX without glaucoma and subjects with PEX who had glaucoma. Random effects model was used to synthesize the data. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated from the allelic, additive, dominant and recessive model. Heterogeneity between studies was assessed using the Q-test and I² statistic.

Results: We identified 70 potentially relevant studies. Among these, 10, 11 and 8 studies of Caucasian populations assessed rs1048661, rs3825942 and rs2165241, respectively, separately in PEX subjects with and without glaucoma. For rs1048661, we found only marginally statistically significant associations with the G allele (10 studies, OR=1.24, 95%CI:1.04-1.47; I²=0%, p=0.644) and the GG genotype of the recessive model (9 studies, OR=1.24 95%CI:1.01-1.52; I²=0%, p=0.485). Also, for rs3825942, we found only marginally statistically significant association with the G allele (11 studies, OR=1.57 95%CI:1.08-2.27; I²=0%, p=0.456). We did not find any other statistically significant association between the allelic, additive, dominant or recessive model of these polymorphisms and risk of glaucoma in subjects with PEX.

Conclusions: Rs1048661 and rs3825942 may be marginally associated with risk of glaucoma in subjects with PEX.

Keywords: 539 genetics