April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Association of LOXL1 polymorphisms with glaucoma risk in subjects with pseudoexfoliation: a meta-analysis
Author Affiliations & Notes
  • Fotis Topouzis
    Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
  • Panayiota Founti
    Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Ophthalmology, St Thomas' Hospital, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
  • Anthoula Chatzikyriakidou
    Laboratory of General Biology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
  • Anna-Bettina Haidich
    Department of Hygiene and Epidemiology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
  • Eleftherios Anastasopoulos
    Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
  • Theofanis Pappas
    Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
  • Ananth C Viswanathan
    NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, University College London (UCL) Institute of Ophthalmology, London, United Kingdom
  • Alexandros Lambropoulos
    Laboratory of General Biology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
  • Footnotes
    Commercial Relationships Fotis Topouzis, None; Panayiota Founti, None; Anthoula Chatzikyriakidou, None; Anna-Bettina Haidich, None; Eleftherios Anastasopoulos, None; Theofanis Pappas, None; Ananth Viswanathan, None; Alexandros Lambropoulos, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 3793. doi:https://doi.org/
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      Fotis Topouzis, Panayiota Founti, Anthoula Chatzikyriakidou, Anna-Bettina Haidich, Eleftherios Anastasopoulos, Theofanis Pappas, Ananth C Viswanathan, Alexandros Lambropoulos; Association of LOXL1 polymorphisms with glaucoma risk in subjects with pseudoexfoliation: a meta-analysis. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3793. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To conduct a meta-analysis of the association of LOXL1 single nucleotide polymorphisms with glaucoma risk in subjects with pseudoexfoliation (PEX), in Caucasians.

Methods: Association studies were retrieved from PubMed, Embase and Web of Knowledge, using 10 July 2013 as cut-off date. Eligibility criteria were applied and data were extracted by two independent investigators. Allelic distributions and genotype frequencies of rs1048661 (R141L), rs3825942 (G153D), and rs2165241 were compared between subjects with PEX without glaucoma and subjects with PEX who had glaucoma. Random effects model was used to synthesize the data. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated from the allelic, additive, dominant and recessive model. Heterogeneity between studies was assessed using the Q-test and I2 statistic.

Results: We identified 70 potentially relevant studies. Among these, 10, 11 and 8 studies of Caucasian populations assessed rs1048661, rs3825942 and rs2165241, respectively, separately in PEX subjects with and without glaucoma. For rs1048661, we found only marginally statistically significant associations with the G allele (10 studies, OR=1.24, 95%CI:1.04-1.47; I2=0%, p=0.644) and the GG genotype of the recessive model (9 studies, OR=1.24 95%CI:1.01-1.52; I2=0%, p=0.485). Also, for rs3825942, we found only marginally statistically significant association with the G allele (11 studies, OR=1.57 95%CI:1.08-2.27; I2=0%, p=0.456). We did not find any other statistically significant association between the allelic, additive, dominant or recessive model of these polymorphisms and risk of glaucoma in subjects with PEX.

Conclusions: Rs1048661 and rs3825942 may be marginally associated with risk of glaucoma in subjects with PEX.

Keywords: 539 genetics  
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