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Fumihiko Mabuchi, Yoichi Sakurada, Seigo Yoneyama, Kenji Kashiwagi, Zentaro Yamagata, Hiroyuki Iijima; Association between GAS7 genetic variant and primary open-angle glaucoma in the Japanese population. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3821.
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It was reported that the growth arrest-specific 7 (GAS7) genetic variants were associated with intraocular pressure (IOP) and primary open-angle glaucoma (POAG) in the Caucasian population. This study was performed to assess whether the GAS7 genetic variant was associated with IOP and POAG in the Japanese population.
Four hundred and twenty-five Japanese patients with POAG, including normal tension glaucoma (NTG, n=213) and high tension glaucoma (HTG, n=212) and 191 control subjects without glaucoma were analyzed for the GAS7 genetic variant (rs11656696). The genotype and allele frequencies were compared between the patients with NTG or HTG and the control subjects. Maximum known IOP in all participants was compared between each genotype.
No significant differences of the genotype and allele frequencies were observed between the patients with NTG (CC: 22.5%, AC: 50.7%, AA: 26.8%, P=0.34; C allele: 47.9%, A allele: 52.1%, P=0.23) or HTG (CC: 21.7%, AC: 47.6%, AA: 30.7%, P=0.38; C allele: 45.5%, A allele: 54.5%, P=0.57) and the control subjects (CC: 16.8%, AC: 53.4%, AA: 29.8%, C allele: 43.5%, A allele: 56.5%). There were no significant differences (P=0.34, analysis of variance) of the maximum IOPs among CC (21.4 ± 8.7mmHg, mean ± standard deviation), AC (20.4 ± 7.1mmHg), and AA (21.3 ± 8.8mmHg) genotypes.
Association between the GAS7 genetic variant and IOP or POAG was not found in the Japanese population.
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