Purchase this article with an account.
Alexander Pinhas, Alexander Gan, Moataz Razeen, Nishit Shah, Eric Cheang, Chun L Liu, Alfredo Dubra, Toco Yuen Ping Chui, Richard B Rosen; Fellow eye in retinal vein occlusion: In vivo microscopic analysis of foveal microvasculature. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3825.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
The prevalence of retinal vein occlusion (RVO) is estimated to be 0.5%, yet its pathogenesis is not completely understood. A number of systemic risk factors have been identified, and RVO may be a terminal thrombotic episode as a consequence of chronic pathological alterations of the vascular wall. In this study, we use adaptive optics scanning light ophthalmoscope fluorescein angiography (AOSLO FA) to map and quantify the foveal microvasculature in affected and fellow eyes.
For 2 central RVO (CRVO) fellow eyes (aged 55 and 28 years old), a superior hemi-central RVO (HRVO) affected eye, and its fellow eye (aged 39 years old), simultaneous reflectance (790nm) and fluorescence (488 nm) image sequences were acquired after fluorescein ingestion using a 1.75° field-of-view to map a 6° square area centered at the fovea. Respective registered averaged images were stitched together to create larger structural and perfusion maps, and compared against one another to identify capillary dropout. For quantitative analysis, perfusion maps were skeletonized and divided into equiangular octants within a 200-800-μm radial annulus centered at the fovea. Data from 0-200μm radially were not used to minimize effect of the foveal avascular zone. Total vessel length and average vessel density were then calculated per annulus for fellow eyes.
All 4 eyes showed capillary dropout (Fig. 1). Quantitative results are presented as mean ± SD. Statistical significance was assessed in comparison to previously acquired data on healthy control and CRVO affected eyes using a two-tailed t-test with a p-value <0.05. Compared to controls, fellow eyes showed a significant decrease in both total vessel length (p=0.0014) and average vessel density (p=0.0018) (Fig. 2). Furthermore, average vessel density of unaffected inferior octants of the superior HRVO eye resembled that of fellow eyes. Fellow eye measurements were greater than those of CRVO affected eyes, but this difference was not significant.
Fellow eye changes may be reflective of chronic pathological processes occurring systemically, and may serve as an early indicator of pathology and increased risk of future venous occlusion.
This PDF is available to Subscribers Only