April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Fellow eye in retinal vein occlusion: In vivo microscopic analysis of foveal microvasculature
Author Affiliations & Notes
  • Alexander Pinhas
    Department of Ophthalmology, New York Eye and Ear Infirmary, New York, NY
    Icahn School of Medicine at Mount Sinai, New York, NY
  • Alexander Gan
    Department of Ophthalmology, New York Eye and Ear Infirmary, New York, NY
  • Moataz Razeen
    Department of Ophthalmology, New York Eye and Ear Infirmary, New York, NY
  • Nishit Shah
    Department of Ophthalmology, New York Eye and Ear Infirmary, New York, NY
  • Eric Cheang
    Department of Ophthalmology, New York Eye and Ear Infirmary, New York, NY
    Stuyvesant High School, New York, NY
  • Chun L Liu
    Department of Ophthalmology, New York Eye and Ear Infirmary, New York, NY
    Bronx Science High School, New York, NY
  • Alfredo Dubra
    Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, WI
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI
  • Toco Yuen Ping Chui
    Department of Ophthalmology, New York Eye and Ear Infirmary, New York, NY
  • Richard B Rosen
    Department of Ophthalmology, New York Eye and Ear Infirmary, New York, NY
    Department of Ophthalmology, New York Medical College, Valhalla, NY
  • Footnotes
    Commercial Relationships Alexander Pinhas, None; Alexander Gan, None; Moataz Razeen, None; Nishit Shah, None; Eric Cheang, None; Chun Liu, None; Alfredo Dubra, Canon USA Inc. (C), US Patent No: 8,226,236 (P); Toco Chui, None; Richard Rosen, Clarity (C), OD‐ OS (C), Optovue (C)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 3825. doi:
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    • Get Citation

      Alexander Pinhas, Alexander Gan, Moataz Razeen, Nishit Shah, Eric Cheang, Chun L Liu, Alfredo Dubra, Toco Yuen Ping Chui, Richard B Rosen; Fellow eye in retinal vein occlusion: In vivo microscopic analysis of foveal microvasculature. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3825.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

The prevalence of retinal vein occlusion (RVO) is estimated to be 0.5%, yet its pathogenesis is not completely understood. A number of systemic risk factors have been identified, and RVO may be a terminal thrombotic episode as a consequence of chronic pathological alterations of the vascular wall. In this study, we use adaptive optics scanning light ophthalmoscope fluorescein angiography (AOSLO FA) to map and quantify the foveal microvasculature in affected and fellow eyes.

 
Methods
 

For 2 central RVO (CRVO) fellow eyes (aged 55 and 28 years old), a superior hemi-central RVO (HRVO) affected eye, and its fellow eye (aged 39 years old), simultaneous reflectance (790nm) and fluorescence (488 nm) image sequences were acquired after fluorescein ingestion using a 1.75° field-of-view to map a 6° square area centered at the fovea. Respective registered averaged images were stitched together to create larger structural and perfusion maps, and compared against one another to identify capillary dropout. For quantitative analysis, perfusion maps were skeletonized and divided into equiangular octants within a 200-800-μm radial annulus centered at the fovea. Data from 0-200μm radially were not used to minimize effect of the foveal avascular zone. Total vessel length and average vessel density were then calculated per annulus for fellow eyes.

 
Results
 

All 4 eyes showed capillary dropout (Fig. 1). Quantitative results are presented as mean ± SD. Statistical significance was assessed in comparison to previously acquired data on healthy control and CRVO affected eyes using a two-tailed t-test with a p-value <0.05. Compared to controls, fellow eyes showed a significant decrease in both total vessel length (p=0.0014) and average vessel density (p=0.0018) (Fig. 2). Furthermore, average vessel density of unaffected inferior octants of the superior HRVO eye resembled that of fellow eyes. Fellow eye measurements were greater than those of CRVO affected eyes, but this difference was not significant.

 
Conclusions
 

Fellow eye changes may be reflective of chronic pathological processes occurring systemically, and may serve as an early indicator of pathology and increased risk of future venous occlusion.

 
 
Fig 1. A) CRVO fellow eye perfusion map with foveal center marked. (B) Zoomed view of perfusion map, compared to (C) structural map, identifies nonperfused capillaries (arrows).
 
Fig 1. A) CRVO fellow eye perfusion map with foveal center marked. (B) Zoomed view of perfusion map, compared to (C) structural map, identifies nonperfused capillaries (arrows).
 
 
Fig. 2. Quantitative results summary.
 
Fig. 2. Quantitative results summary.
 
Keywords: 688 retina • 749 vascular occlusion/vascular occlusive disease • 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound)  
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