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Howard F Fine, Daniel B Roth, Sumit P Shah, Tahia Haque, Harold M Wheatley; Intraocular Inflammation Following Aflibercept (Eylea) Injection. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3855.
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© ARVO (1962-2015); The Authors (2016-present)
To report the characteristics and frequency of intraocular inflammation following intravitreal aflibercept injection.
Retrospective case series of consecutive patients who received intravitreal aflibercept in a group retina practice from November 2011 through June 2013.
There were 28 cases of intraocular inflammation following a total of 5905 aflibercept injections among 1660 patients. The mean baseline acuity was 20/57 which decreased to 20/179 at diagnosis (p<0.0001), but recovered to 20/59 at month 1, 20/57 at month 3, and 20/52 at month 6 (p=NS). Vitreous culture and injection of antibiotics was performed in 8 cases, all were culture negative; the remainder received only topical corticosteroids.
The frequency of inflammation following aflibercept was 0.47% per injection. Visual acuity and inflammation returned to baseline within 1 month in most cases with topical corticosteroids.
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