Abstract
Purpose:
To report the characteristics and frequency of intraocular inflammation following intravitreal aflibercept injection.
Methods:
Retrospective case series of consecutive patients who received intravitreal aflibercept in a group retina practice from November 2011 through June 2013.
Results:
There were 28 cases of intraocular inflammation following a total of 5905 aflibercept injections among 1660 patients. The mean baseline acuity was 20/57 which decreased to 20/179 at diagnosis (p<0.0001), but recovered to 20/59 at month 1, 20/57 at month 3, and 20/52 at month 6 (p=NS). Vitreous culture and injection of antibiotics was performed in 8 cases, all were culture negative; the remainder received only topical corticosteroids.
Conclusions:
The frequency of inflammation following aflibercept was 0.47% per injection. Visual acuity and inflammation returned to baseline within 1 month in most cases with topical corticosteroids.
Keywords: 513 endophthalmitis •
557 inflammation •
462 clinical (human) or epidemiologic studies: outcomes/complications