April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Reduced-fluence photodynamic therapy in polypoidal choroidal vasculopathy patients non-responding to ranibizumab
Author Affiliations & Notes
  • Ik Soo Byon
    Ophthalmology, Pusan National University Yangsan Hospital, Yangsan-si, Republic of Korea
    Research Institute for Convergence of Biomedical Science and Technology, Yangsan, Republic of Korea
  • Sung Who Park
    Ophthalmology, Pusan National University Hospital, Busan, Republic of Korea
  • Ji Eun E Lee
    Ophthalmology, Pusan National University Hospital, Busan, Republic of Korea
    Medical institute, School of medicine, Pusan National University, Pusan, Republic of Korea
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 3883. doi:
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    • Get Citation

      Ik Soo Byon, Sung Who Park, Ji Eun E Lee; Reduced-fluence photodynamic therapy in polypoidal choroidal vasculopathy patients non-responding to ranibizumab. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3883.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To evaluate the effect of reduced-fluence photodynamic therapy (PDT) on polypoidal choroidal vasculopathy (PCV) non-responding to intravitreal ranibizumab.

Methods: PCV patients who were initially treated with three monthly injections of ranibizumab were retrospectively surveyed. Non-responders were defined as patients having no reduction of intra/subretinal fluid after 3 consecutive injections, and were treated with reduced-fluence PDT.

Results: Of 104 eyes, twenty two (21.2%) eyes were non-responders. Sixteen eyes of the non-responders received reduced PDT. Nine eyes achieved a complete resolution of fluid, and six had reduced but remaining fluids. One had sustained fluids at 6 months, even after undergoing an additional anti-VEGF injection after reduced PDT. The mean macular thickness was reduced significantly at 3 and 6 months, but the mean visual acuity was worse than baseline.

Conclusions: Reduced-fluence PDT in non-responders resulted in fluid reduction gradually for several months, but did not maintain visual acuity.

Keywords: 647 photodynamic therapy • 453 choroid: neovascularization  
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