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Giulia Caminiti, Enrico Peiretti, Maurizio Fossarello, Francesco Meloni; Photodynamic theraphy versus intravitreal injection of anti-VEGF as treatment for macular serous detachment in tilted disc syndrome.. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3976.
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© ARVO (1962-2015); The Authors (2016-present)
To describe a consecutive series of patients with tilted disc syndrome who presented macular serous detachment treated with photodynamic therapy (PDT) or intravitreal injection (IVT) of anti-VEGF.
10 eyes of 7 consecutive patients followed in our center between 3 months and 2 years with tilted disc syndrome, who showed presence of sub retinal macular fluid on optical coherence tomography (OCT) scan, were evaluated also with fluorescein and indocyanine angiography (FA, ICG), in order to define any further physiopathological macular alteration. Patients was classified in 3 groups. First group were 3 eyes treated with photodynamic therapy (PDT), second group were 4 eyes treated with intravitreal injection (IVT) of anti-VEGF (Bevacizumab), third group were 3 eyes treated with combination therapy (PDT + IVT). Each patient performed fluorescein and indocyanine angiography, optical coherence tomography at baseline and at scheduled visits.
First group (only PDT) showed in 100% of eyes an improvement of BCVA and a partial reduction of subretinal fluid on OCT scan, mean treatment was 2 PDT. In second group of patients (only Bevacizumab) 100% of eyes maintained BCVA and subretinal fluid was stable, mean treatment was 2 IVT. In third group of patients BCVA was maintained and subretinal fluid showed partial reduction in 66,66% of eyes, in 33,33% of eyes BCVA and subretinal fluid were stable.
Patients affected by neurosensory macular detachment in tilted disc syndrome showed improvement or stabilization of BCVA and partial reduction of subretinal fluid on OCT scan when treated with PDT. Therapy with intravitreal injections of antiVEGF seems to be not effective.
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