Detection of polypoidal lesions in polypidal choroidal vasculopathy with high-penetration high-sensitive optical coherence angiography

Abstract

 

Purpose

 

To evaluate the polypoidal lesion detectability in polypoidal choroidal vasculopathy with high-penetration optical coherence angiography (HP-OCA).

 

Methods

 

We prospectively examined 17 eyes of 17 patients with polypoidal choroidal vasculopathy using 1060 nm high-penetration swept-source Doppler optical coherence tomography (OCT). The scanning range was 6.0 x 6.0 mm on the retina with 256 A-scans×2048 B-scans, and scanning speed was 100,000 A-scan/s. High sensitive vascular image was calculated from the phase resolved Doppler analysis using two A-lines in two successive B-scans. Three-dimensional vascular images (HP-OCA) were compared with indocyanine green angiography images, and evaluate the detectability of polypoidal lesions with HP-OCA.

 

Results

 

With Doppler B-scan OCT images, blood flows at polyoidal lesions were clearly detected in all eyes. All polypoidal lesions were located in the space between the Bruch’s membrane and retinal pigment epithelium. In en-face projection images of HP-OCA, polypoidal lesions could be detected in all eyes. Polypoidal lesions were clearly observed in 9 eyes, and somewhat obscured in 8 eyes. HP-OCA findings of polypoidal lesions were similar to early phase of indocyanine green angiography images.

 

Conclusions

 

Polyoidal lesions could be detected with HP-OCA. HP-OCA is useful for non-invasive assessment of polypoidal choroidal vasculopathy.

 

 

Keywords: 412 age-related macular degeneration • 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • 550 imaging/image analysis: clinical