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Riccardo Vinciguerra, Emanuela F Legrottaglie, Pietro Rosetta, Claudio Azzolini, Paolo Vinciguerra; Iontophoresis Corneal Collagen Cross Linking for Progressive Keratoconus. Invest. Ophthalmol. Vis. Sci. 2014;55(13):4212.
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© ARVO (1962-2015); The Authors (2016-present)
The aim of this study is to report the preliminary clinical results of transepithelial corneal collagen cross-linking (CXL) with Iontophoresis.
Ten eyes of ten patients with progressive keratoconus were included in this prospective clinical study. Best corrected visual acuity (BCVA), sphere and cylinder refraction, corneal topography, scheimpflug tomography, aberrometry, anterior segment optical coherence tomography (AS-OCT) and endothelial cell count were assessed at baseline and at 1, 3 and 6 months of follow up. The parameters considered to establish keratoconus progression always were proved with differential maps as change in curvature in the cone area of at least 1 diopters obtained with an istantaneous map.
Functional parameters showed a significant improvement (p<0.05) of BCVA after 6 months of follow up together with a significant decrease of sphere. Conversely morphological parameters showed a non significant reduction of topographic parameters and a significant increase in minimum pachymetry after 6 months of follow up. None of the patients had continuous progression of keratoconus or had to repeat crosslinking procedures. Endothelial cell counts did not changed significantly (p>0.05).
Despite the low number of patients and a short term follow up our preliminary results on transepithelial corneal collagen cross-linking with iontophoresis indicate a stabilization and a significant improvement of functional parameters till 6 months of follow up after the treatment.
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