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Ah Ran Cho, Jin Young Rhew, Kyu-Ryong Choi, Ewha Institute of Ophthalmology and Optometry; The Effects of Prostaglandin Analogues on the Corneal Biomechanical Factors in Normal Tension Glaucoma. Invest. Ophthalmol. Vis. Sci. 2014;55(13):4234.
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To analyze the effects of prostaglandin analogues (PGAs) treatment on intraocular pressure (IOP), central corneal thickness (CCT) and corneal biomechanical properties in normal tension glaucoma patients.
This prospective study included 20 eyes from 20 subjects diagnosed with normal tension glaucoma who were initiated PGAs therapy. Corneal hysteresis (CH), corneal response factor (CRF), corneal-compensated IOP (IOPcc), and Goldmann correlated IOP (IOPg) were measured using Ocular response analyzer (ORA) before the start of therapy. Goldmann applanation tonometry (GAT) and CCT were also measured. Subjects were randomly assigned to be treated with either latanoprost, bimatoprost, or travoprost. All measurements were performed after 1 month of therapy.
The mean age was 49.6 ± 12.1 years, and 13 subjects were male. The mean GAT decreased from 15.0 to 12.5 mmHg (p<0.001). On the other hand, the mean CH increased from 9.3 ± 1.3 mmHg to 10.5 ± 1.3 mmHg (p<0.001). The mean CRF decreased from 9.6 ± 2.0 mmHg to 9.2 ± 0.9 mmHg, but it was not statistically significant. The mean IOPg significantly decreased from 16.5 mmHg to 13.1 mmHg (p<0.001). There were no significant differences in IOPcc and CCT before and after topical PGAs therapy. There were no significant correlations between the IOP reduction and the corneal biomechanical properties.
Our results suggest that CH was influenced by PGAs therapy in normal tension glaucoma. Corneal biomechanical properties were not associated with IOP reduction.
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