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Boonsong Wanichwecharungruang, Doreen Wagner, Aungnapa Kongthaworn; Comparative study of lamina cribrosa thickness between primary angle-closure- and primary open-angle glaucoma. Invest. Ophthalmol. Vis. Sci. 2014;55(13):4250.
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To compare lamina cribosa (LC) thickness, determined by the enhanced depth imaging (EDI) mode of the Heidelberg Spectralis spectral domain optical coherence tomography (OCT), of primary angle-closure glaucoma (PACG) and primary open-angle glaucoma (POAG).
We included 34 PACG, 38 POAG, and 62 controls in this cross-sectional study. Lamina cribosa thickness was determined at the center of the optic nerve head obtained by EDI-OCT. Nine points of LC thickness were measured. Averages of those LC thicknesses were analyzed.
The mean age was not different between glaucoma and control. Mean age, number of glaucoma medication, current IOP, C:D ratio, MD and PSD of visual field, was not significantly different between PACG and POAG. However, the maximum IOP was higher in PACG than in POAG, 32.5 (10.5) vs. 25.4 (6.2) mmHg (p = 0.001). Axial length in PACG was shorter than in POAG, 22.9 (0.8) vs. 23.7 (0.8) mm (p = 0.000). The LC thicknesses were significantly different among PACG, POAG, and control groups. Mean (SD) LC thicknesses were 226.99 (31.08), 257.17 (19.46), and 290.75 (28.02) μm, respectively (p = 0.000).
The EDI-OCT detected differences in the LC by glaucoma type. The lamina cribrosa was thinner and the maximum IOP was higher in PACG than in POAG. Our result supports the IOP dependent mechanism of glaucomatous optic nerve damage.
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