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Takuhei Shoji, Masayuki Suzuki, Hiroto Kuroda, Masanori Hangai, Makoto Araie, Shin Yoneya; Correlation between Myopia, Glaucoma and Lamina Cribrosa Tilt Angle Using Broad Wavelength Laser Optical Coherence Tomography.. Invest. Ophthalmol. Vis. Sci. 2014;55(13):4256.
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To measure horizontal and vertical lamina cribrosa (LC) tilt angle and investigate the associated factors using wide-wavelength, Laser optical coherence tomography (OCT).
This Laser OCT system based on 200nm bandwidth spectrometer laser light source was used, enabling in vivo cross sectional optic nerve imaging with 2μm axial resolution. A total of 300 optic nerve head B-scans, were obtained by 10um step and identified the inner edge of Bruch membrane opening (BMO) as the reference plane. Vertical and horizontal angle of the surface of LC were measured and the potential associated factors was estimated with univariate and multivariate logistic regression analysis.
Fifty-three eyes (from 31 patients) were enrolled in this study. The mean age ± standard deviation was 51.0±17.3 years in no glaucoma eyes, and 63.2±8.7 years in glaucoma eyes, respectively. The median (interquartile range, [IQR]) horizontal and vertical tilt angle were 7.10 (2.43-11.45) degrees and 4.15 (2.60-6.85) degrees in no glaucoma eyes, and 8.50 (4.40-14.10) degrees and 9.30 (6.90-14.15) degrees in glaucoma eyes. The refractive errors had a statistically significant association with horizontal lamina tilt angle (Coefficients, -1.53 per diopter; p< 0.001), and glaucoma had a significant correlation with vertical tilt angle (Coefficients, 3.28; p<0.001) using multiple logistic regression analysis.
The horizontal and vertical LC tilt angles were significantly correlated with refractive errors and glaucoma, respectively. These parameters have important implication for investigation of the correlation between myopia, glaucoma and LC morphological features.
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