Purchase this article with an account.
Thasarat S Vajaranant, Shaung Wu, Chunyi Hsu, Mina Torres, Rohit Varma, The Chinese American Eye Study; The Relationship between Intraocular Pressure and the Peripapillary Retinal Nerve Fiber Layer Thickness in Chinese Americans without Eye Disease: The Chinese American Eye Study. Invest. Ophthalmol. Vis. Sci. 2014;55(13):4279.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To explore the relationship between intraocular pressure (IOP) on the peripapillary retinal nerve fiber layer (pRNFL) thickness in Chinese Americans without any evidence of eye disease.
We analyzed data from the CHES, the first population-based study of 4582 Chinese-Americans aged 50 years and older in Monterey Park, California. The participants completed a comprehensive eye exam including measurements of the pRNFL thickness by the Cirrus SD-OCT. Participants with glaucoma, age-related macular degeneration, diabetic retinopathy, and high myopia (> 6 diopters) were excluded from this analysis. One eye from each participant was randomly selected for this analysis. Linear regression models were used to determine the relationship of age, sex, hypertension, diabetes, axial length (AL), spherical equivalent, IOP, central corneal thickness, and ocular perfusion pressure on the pRNFL thickness.
The final analysis included one eye of 3961 participants with a mean age of 61.5±8.9 years (63.8% females). In this cohort, the mean IOP was 15.2 ± 2.9 mmHg, and the mean global pRNFL thickness was 94.6 ± 13.2 µm. Thinner pRNFL was associated with older age (p <.0001); being male (p = 0.01); having hypertension (p = 0.04); having type 2 diabetes (p < .0001); longer AL (p < .0001); more myopic refractive error (p < .0001); and higher IOP (p <.0001). For every decade of older age, the pRNFL is thinner by 3.5 µm (95% confidence interval (CI), 3.0-4.0 µm). With every 10-mmHg-increase in IOP, the pRNFL is thinner by 2.7 µm (95% CI, 1.5-4.0).
Our findings represent the first epidemiologic analyses of the pRNFL thickness in the Chinese Americans without eye disease. Given that higher IOP was associated with thinner pRNFL, IOP may need to be taken into account when assessing the pRNFL thickness for diagnosis and follow-up of glaucoma.
This PDF is available to Subscribers Only