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Christopher C Teng, Ruojin Ren, Mugen Liu, Gustavo V De Moraes, Lam Lu, Sung Chul Park, Jeffrey M Liebmann, Robert Ritch; Volumetric Assessment of the Cornea, Anterior Chamber and Iris using Swept-Source Optical Coherence Topography in Pigment Dispersion Syndrome and Normal eyes. Invest. Ophthalmol. Vis. Sci. 2014;55(13):4280.
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© ARVO (1962-2015); The Authors (2016-present)
To compare cornea, anterior chamber and iris volumes between normal and pigment dispersion syndrome (PDS) eyes using swept-source optical coherence tomography (SS-OCT).
Volumetric radial scans of the cornea, anterior chamber and iris were performed using SS-OCT (Casia SS-1000; Tomey, Nagoya, Japan) in ambient light. Total, superior, inferior, nasal, and temporal quadrant volumes (mm3) were calculated for the cornea, anterior chamber, and iris in normal and pigment dispersion syndrome eyes, using the built-in software.
20 PDS eyes (10 patients; mean age, 42.6±11.7 years) and 16 normal eyes (11 patients; mean age, 38.4±12.0 years) were included. Compared to normal eyes, PDS eyes had greater total cornea volume (147.7±10.1 vs 133.5±11.3, p <0.01) and greater total anterior chamber volume (239.5±28.9 vs 179.3±35.1, p<0.01). There was no difference in total iris volume (44.4±4.7 vs 45.1±4.5, p=0.67) between the two groups. In PDS eyes, the superior quadrant cornea volume (34.0) (mm3) was less than the nasal (36.7), temporal (37.5) and inferior (39.5) quadrant volumes (p<0.01); but there was no difference in the anterior chamber volume (p=0.5) and iris volume (p=0.06) between the four quadrants. In normal eyes, the superior quadrant cornea volume (29.6) (mm3) was less than the nasal (33.9), temporal (35.3) and inferior (35.2) quadrant volumes (p<0.01); the superior quadrant anterior chamber volume (41.5) was also less than the nasal (42.8), temporal (46.8), and inferior (48.2) quadrant volumes, (p=0.04); and the superior iris volume (11.7) was greater than the nasal (10.8), temporal (11.2) and inferior (11.4) quadrant volumes (p=0.05).
Cornea and anterior chamber volumes are greater in PDS eyes compared to normal eyes. Differences in anterior chamber and iris volume may become less pronounced in PDS. Imaging the cornea, anterior chamber and iris using SS-OCT may be beneficial to help better understand the pathophysiology of PDS.
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